Biology
Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 3.6, Problem 2CC
Summary Introduction

To determine: The difference in the interaction between two proteins if the structure of one protein is altered.

Introduction: Tertiary or quaternary proteins are of different type like: globular proteins, enzymes and so on. These proteins interact or bind with each other by the different type of forces like (hydrogen bonds, Van der Waals forces, ionic bonds, and hydrophobic bonds). The interaction between an enzyme and its substrate or interaction between two globular proteins all these interactions include bond formation.

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A recent genome sequencing project for the bacterium Burkholderia mallei has identified a new protein with high similarity to the lysylphosphatidylglycerol flippase enzyme. A short section of the new protein sequence is shown below. TVEVNAPGDVQKALSELQQINDGRLDIRI (a) Are any reverse turns likely to be present? Explain your answer. (b) Are any beta-strands likely to be present? Explain your answer. (c) Are any alpha helices likely to be present? Explain your answer. (d) Is any supersecondary structure likely to be present? Explain your answer. (e) Identify two residues that are likely to be buried in the core of the folded protein. Explain your answer. (f) Identify two residues that are likely to be hydrogen bonded to each other. Explain your answer.
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Assume that the translational error frequency, d, is 1 * 10–4. (a) Calculate the probability of making a perfect protein of 100 residues. (b) Repeat for a 1000-residue protein.
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