Concept explainers
a. Consider the malate dehydrogenase reaction, which is part of the citric acid cycle:
malate + NAD+
In yeast mitochondria, where the pH= 8.1, this reaction is exergonic only at low oxaloacetate concentrations. Assuming a pH = 8.1, a temperature of 37o C, and the steady-state concentrations given below, calculate the maximum concentration of oxaloacetate at which the reaction will still be exergonic.
b. How would a drop in pH affect
c. How would an increase in intracellular malate levels affect
d. How would an increase in intracellular pyruvate levels affect
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Biochemistry: Concepts and Connections (2nd Edition)
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