Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 26, Problem 29ESP
A number of comparisons of
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n class we investigated the reason cystic fibrosis is maintained in the human population in higher frequency than we expected given the deleterious effects of being homozygous at the CFTR gene. We calculated the actual mutation rate of the CFTR gene to be 6.7 x 10-7. The mutation rate expected under mutation-selection balance was 4 x 10-4. What is the most plausible explanation as to why cystic fibrosis is maintained in the human population at a higher frequency than we expect?
a.
Negative selection against the CFTR deleterious alleles is too weak to eliminate the alleles from the human population.
b.
Positive selection for the CFTR deleterious alleles is likely occurring in response to some other selective pressure in the human population, possibly resistance to typhoid fever.
c.
The CFTR gene has an exceedingly low mutation rate causing humans to have no genetic variation at that gene.
d.
The CFTR gene has an exceedingly high mutation rate and that is…
Recently, scientists have identified a mutation that is found at high frequency in Finnish populations, located in northern Europe where the winter is very cold. This mutation is believed to be a “cold sensitive” allele that warns people of extreme cold temperatures. Could this allele have undergone a “selective sweep”, if it had suddenly appeared in this northern population of humans? How would such a selective sweep be detected with genome data?
In the year 2374, humans finally developed the technology necessary for time travel. You are a scientist interested in the population genetics of extinct animals. Taking advantage of this technology advance, you decide to travel back 8 million years to conduct field work in Venezuela. You are studying a population of Phoberomys pattersoni, the world’s largest extinct rodent weighing approximately 700 kg (1500 lbs) and looking vaguely like a giant guinea pig. The coat color of this rodent varies between tan (dominant) and brown (recessive). Assume the population is in Hardy-Weinberg equilibrium. You observed 336 tan Phoberomys and 64 brown Phoberomys during your study.
What is the frequency of the homozygous recessive genotype? ________________
What is the allelic frequency of the dominant (tan) allele in the population? ___________
Of the animals you observed, how many were heterozygous? _______________
As you observe the animals you count 200 brown and 450 tan. Conduct a…
Chapter 26 Solutions
Concepts of Genetics (12th Edition)
Ch. 26 - The ability to taste the compound...Ch. 26 - Determine whether the following two sets of data...Ch. 26 - If the albino phenotype occurs in 1/10,000...Ch. 26 - A prospective groom, who is unaffected, has a...Ch. 26 - In a region of Quebec, Canada, 1 in 22 people are...Ch. 26 - Critics argue that a uniform panel of disorders...Ch. 26 - Others argue that the current testing system...Ch. 26 - HOW DO WE KNOW? Population geneticists study...Ch. 26 - CONCEPT QUESTION Read the Chapter Concepts list on...Ch. 26 - Price et al. [(1999).J. Bacteriol181:2358-2362)...
Ch. 26 - The genetic difference between two Drosophila...Ch. 26 - The use of nucleotide sequence data to measure...Ch. 26 - Prob. 6PDQCh. 26 - What must be assumed in order to validate the...Ch. 26 - In a population where only the total number of...Ch. 26 - If 4 percent of a population in equilibrium...Ch. 26 - Consider a population in which the frequency of...Ch. 26 - If the initial allele frequencies are p = 0.5 and...Ch. 26 - Under what circumstances might a lethal dominant...Ch. 26 - Assume that a recessive autosomal disorder occurs...Ch. 26 - One of the first Mendelian traits identified in...Ch. 26 - Describe how populations with substantial genetic...Ch. 26 - Achondroplasia is a dominant trait that causes a...Ch. 26 - Prob. 17PDQCh. 26 - Prob. 18PDQCh. 26 - A botanist studying water lilies in an isolated...Ch. 26 - A farmer plants transgenic Bt corn that is...Ch. 26 - In an isolated population of 50 desert bighorn...Ch. 26 - To increase genetic diversity in the bighorn sheep...Ch. 26 - What genetic changes take place during speciation?Ch. 26 - Some critics have warned that the use of gene...Ch. 26 - Prob. 25PDQCh. 26 - What are the two groups of reproductive isolating...Ch. 26 - A form of dwarfism known as Ellisvan Creveld...Ch. 26 - The original source of new alleles, upon which...Ch. 26 - A number of comparisons of nucleotide sequences...Ch. 26 - Shown below are two homologous lengths of the...Ch. 26 - Recent reconstructions of evolutionary history are...
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- The Out of Africa hypothesis (also called the African Replacement hypothesis) proposes that Homo sapiens arose in Africa and evolved there for several hundred thousand years. Then, some 85,000 years ago, a small band of Homo sapiens migrated out of Africa and populated the remainder of the world. Based on this hypothesis, what predictions would you make about worldwide human variation in mtDNA?arrow_forwardYou have collected and determined genotypes of 200 individuals from a population of thr fruit fly, Drosophila pseudoobscura. Your sequencing study revealed 20 individuals with genotype AA, 70 individuals with genotype Aa and 110 individuals with genotype aa. i) what are your theoretical expectations for the number of individuals with each genotype if the population is in Hardy-Weinberg equilibrium. ii) Based on the genotype counts observed, is there evidence that this population of fruit flies deviates from your theoretical expectations under Hardy-Weinberg equilibrium?arrow_forwardWyckoff et al. (2000. Nature 403:304-309) have proposed that some human male reproductive-associated genes have evolved by natural selection and not by neutral evolution. Part of the DNA sequence results of their study is shown below. Which gene(s) did seem to evolve by natural selection? Note: dn = number of substitutions per non-synonymous (replacement) sites and ds = number of substitutions per synonymous (silent) sites. dn ds Acrosin-Trypsin 0.138 0.064 Protamine 1 0.133 0.046 SRY 0.055 0.090 Histone H1 (testicular) 0.055…arrow_forward
- You conduct an exercise in the Darwinian Snails Sim-U-Text lab. You simulate conditions under which survival of snails is selective-that is, snails with thicker shells are less likely to be preyed on by crabs than snails with thinner shells. The default settings also ensure the trait is heritable, and the population has variation in this trait. You allow mutations to occur. As you run the simulation, you observe that the mean shell thickness of the population increases over successive snail generations. Have you successfully simulated natural selection? No, because no snails appeared with thicker shells than the thickest shells observed in the initial population O Yes, because crabs preyed on the snails O No, because you cannot have selection with mutations operating No, because the changes in shell thickness could have been due to genetic drift O Yes, because there was a change in the mean shell thickness Yes, because there were mutationsarrow_forwardLion populations are found all over sub- Saharan africa. How do the sequences above reinforce or contradict the idea that populations of lions who are genetically similar live in the same geographic area?arrow_forward5) This chart shows the fur colors of a population of rabbits in the Great Smoky Mountains. A mutation introduces an allele for white fur. Based on the data, what do you predict will happen in the next 20 years? Select ALL that apply. Not Graded A) Those with white fur will slowly increase over the next 20 years. B) Those with mottled fur and brown fur will continue to exist in the population. C) Those with white fur will continue to decrease or even die out of the population. D) Mottled fur is the dominant trait so it will continue to increase in the population. E) Unless the environment changes, those with mottled fur will continue to increase in number.arrow_forward
- Name crickets remain unnoticed by the parasitoid flies. To test this idea, Robin dissected the otS males to look for fly larvae. She compared A infection levels for 67 normal males- collected before the flatwing mutation appeared in the population-to 122 flatwing males that she collected after the flatwing mutation appeared. She expected fewer males to be infected by the parasitoid fly after the appearance of the flatwing mutation in the cricket population. Scientific Questions: Why do most male crickets on Kauai have flat wings? Could parasitoid flies have contributed to the loss of song for male crickets? Figure 2: A parasitoid fly, Ormia ochracea, sitting on top of its cricket host, Teleogryllus oceanicus. What is the hypothesis? Find the hypothesis in the text and underline it. A hypothesis is a proposed explanation for an observation, which can then be tested with experimentation or other types of studies. Scientific Data: Use the data below to answer the scientific questions:…arrow_forward1) This model shows the process of natural selection on rabbits demonstrating variation in fur color over several generations. Using the model, what most likely led to the loss of white furred rabbits in the population? 21 A) XB) 9) The white rabbits did not reproduce fast enough to survive. White was a recessive trait and therefore not passed on to any offspring. The white fur was a favorable trait but was never prevalent in the population. The rabbits with white fur had less camouflage in D) the environment and were more easily preyed on by predators. If this model continues, with no major changes to the environment,arrow_forwardThe remote South Atlantic island of Tristan da Cunha was first colonized in 1818 by exactly 20 people, 12 men and 8 women. It’s reasonable to assume that the starting genetic variation in the population was high – the men were all English while the women were primarily of African descent- so we’ll say that heterozygosity was 0.5. The breeding sex ratio in this starting population was 1:1 (which each woman having children with only a single man). Let’s also assume that the generation time across this time interval has been constant at 20 years. 1a. If these conditions held constant – what would the expected heterozygosity be in the population today (2018 to deal with a clean integer value for generations)? 1b. In 1884 the population had grown to 106 when disaster struck the island. Of the 19 adult men on the island, 15 were in the same fishing boat that capsized, leaving only 4 adult men alive on the island. These desperate times may have changed the sex ratio of the breeding population…arrow_forward
- The genome size of humans and chimpanzees are both approximately 3 billion base pairs, sharing about 96% identical sequences. The 4% difference in their genomes is most likely the result of natural selection selecting for different sequences for adapting to different habitats. a)True b)Falsearrow_forwardThis model shows the process of natural selection on rabbits demonstrating variation in fur color over several generations. Using the model, what most likely led to the loss of white furred rabbits in the population? A) the white rabbits did not reproduce fast enough to survive B) white was a recessive trait and therefore not passed on to any offspring C) the white fur was a favorable trait but was never prevalent in the population D) the rabbits with white fur had less camouflage in the environment and were more easily preyed on by predatorsarrow_forwardTrue or False a.) Evolution creates genetic variation in a population. b.) Fitness refers to an allele's ability to help the organism evade predators. c.) The process of natural selection may increase or decrease the frequency of a particular allele in the population depending on the environment. d.) A potato species acquires a mutation in its catalasegene that allows it to function in very cold environments. However, this catalaseis denatured at room temperature. This is a good example of fitness cost.arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY