Concept explainers
(a)
Interpretation: To determine whether glutamate can be converted to
Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an
During transamination reaction the new keto acid formed has carbon skeleton similar to the carbon skeleton of the reacting amino acid and the new amino acid formed has the carbon skeleton similar to the carbon skeleton of the reacting keto acid.
(a)
Answer to Problem 26.32EP
Yes, glutamate can be converted to
Explanation of Solution
Glutamate is an amino acid and its structure is:
Both glutamate and
(b)
Interpretation: To determine whether
Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an
During transamination reaction the new keto acid formed has carbon skeleton similar to the carbon skeleton of the reacting amino acid and the new amino acid formed has the carbon skeleton similar to the carbon skeleton of the reacting keto acid.
(b)
Answer to Problem 26.32EP
Yes,
Explanation of Solution
Glutamate is an amino acid and its structure is:
Both glutamate and
(c)
Interpretation: To determine whether glutamate can be converted to aspartate via a transamination reaction or not.
Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an
During transamination reaction the new keto acid formed has carbon skeleton similar to the carbon skeleton of the reacting amino acid and the new amino acid formed has the carbon skeleton similar to the carbon skeleton of the reacting keto acid.
(c)
Answer to Problem 26.32EP
No, glutamate cannot be converted to aspartate by transamination.
Explanation of Solution
Glutamate is an amino acid and its structure is:
Aspartate is an amino acid and its structure is:
Transamination reaction involves the exchange of an amino group from an
(d)
Interpretation: To determine whether
Concept introduction: Transamination reaction is a biochemical reaction that involves the transfer of an amino group. In transamination reaction exchange of an amino group from an
During transamination reaction the new keto acid formed has carbon skeleton similar to the carbon skeleton of the reacting amino acid and the new amino acid formed has the carbon skeleton similar to the carbon skeleton of the reacting keto acid.
(d)
Answer to Problem 26.32EP
No,
Explanation of Solution
Oxaloacetate is a keto acid and its structure is:
Transamination reaction involves the exchange of an amino group from an
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Chapter 26 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
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- Fatty acids are converted to their coenzyme A esters in a reversible reaction catalyzed by acyl-CoA synthetase: R-COO +ATP +COA R-C-COA +AMP + PPi a) The reaction involves two steps the first of which forms an enzyme-bound intermediate identified as the mixed anhydride of the fatty acid and AMP: R-C-O-P-O-nibose-adenine Write two chemical equations coresponding to the two steps of the reaction catalyzed by the synthetase. b) The acyl-CoA synthetase reaction as written above is readily reversible. How might the reaction be made to favor formation of fatty acyl-CoA? Write within the box. Anything outside the box will not be graded. From thearrow_forwardUDP-glucuronosyltransferase enzymes bind the organic compound UDP-glucuronic acid (UDP-GA) in order to catalyse the transfer of a glucuronic acid group from UDP-GA to a drug molecule, releasing UDP from the active site as a product. UDP is then regenerated by the activity of another enzyme. What terms could be used to describe UDP-GA?arrow_forwardPyridoxal phosphate acts as an intermediate carrier of amino groups during transamination reactions. Write a series of reactions to show the role of pyridoxal phosphate in the transamination reaction involving alanine and α-ketoglutarate.arrow_forward
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- Why would glutamate utilize the oxidative deamination pathway over transamination – especially if removal of NH4+ requires ATP? Would it not be favorable for the body to just use transamination?arrow_forwardWhat is alpha keto glutarate dehydrogenase complex?. explain very briefly.arrow_forwardConsidering that triacylglycerols get hydrolyzed in the small intestine because of pancreatic lipases, write the reactions using structural formulas by which a 7-carbon fatty acid is activated and oxidized in the liver of this patient. Indicate cofactors and underscore the final CoA products.arrow_forward
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