Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 25, Problem 20E
Summary Introduction

To explain: The reason behind the compounds that inhibits the activity of DNA polymerases enzyme would be an effective anticancerous agent.

Introduction: DNA polymerase is an important enzyme that plays an essential role in the polymerization of nucleotides to form DNA double helical structure. It adds deoxyribonucleotide triphosphates (dNTPs act as a substrate for DNA pol) to the structure. However, the oxidized form of dNTP inhibits this enzyme. Therefore, oxidized dNTPs can act as an anti-cancerous agent in the cell.

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