Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 25, Problem 16E
Summary Introduction

To determine: The base to which the modified cytosine pairs.

Concept introduction: A base analogue is a chemical that has a similar structure of either a purine or a pyrimidine. Hydroxylamine (NH2OH) is an inorganic chemical that is capable of inducing transition mutation in the DNA structure. One such mutagenic effect converts cytosine to a modified cytosine, which pairs with adenine rather than pairing with guanine. This is an example for transition mutation.

Summary Introduction

To explain: Whether a modified cytosine base-pair addition generates transition or transversion mutation.

Concept introduction: A base analogue is a chemical which has a similar structure to that of either a purine or a pyrimidine. Hydroxylamine (NH2OH) is an inorganic chemical that is capable of inducing transition mutation in the DNA structure. One such mutagenic effect converts the cytosine to a modified cytosine, which pair with adenine rather than pairing with guanine. This is an example for transition mutation.

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY