Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 24.4, Problem 2CC
Summary Introduction
To predict: The effect of the expression of Drosophila’s eyeless gene on the tip of the mouse’s tail.
Introduction: The Pax6 (paired box) is a transcription factor protein-encoding gene that controls the regulation of expression of many different genes. This gene is known to coordinate the development of the eye in rats and humans. Any mutation in the gene can cause underdevelopment leading to small eyes.
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Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network?
Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network? (c) Are genetic networks likely to specify developmental processes in general? Explain fully and provide an example.
provide one example from the Drosophila AP toolkit for "Toolkit genes can be classified according to the phenotypes caused by their mutation. Similar mutant phenotypes often reflect genes that function in a single developmental pathway. Distinct pathways exist for the generation of body axes, for example, and for the formation and identity of fields."
Chapter 24 Solutions
Biology
Ch. 24.1 - Can you think of another example of two different...Ch. 24.1 - Prob. 1CSCh. 24.1 - Is temporal isolation an example of a prezygotic...Ch. 24.1 - Prob. 3CCCh. 24.2 - Prob. 1CSCh. 24.2 - Prob. 1EQCh. 24.2 - Prob. 2EQCh. 24.2 - Prob. 3EQCh. 24.2 - Prob. 1CCCh. 24.2 - Prob. 2CC
Ch. 24.4 - Evo-Devo: Evolutionary Developmental Biology...Ch. 24.4 - Prob. 1CSCh. 24.4 - Prob. 2CCCh. 24 - Macroevolution refers to evolutionary changes that...Ch. 24 - Prob. 2TYCh. 24 - Prob. 3TYCh. 24 - Prob. 4TYCh. 24 - Prob. 5TYCh. 24 - Prob. 6TYCh. 24 - Prob. 7TYCh. 24 - Prob. 8TYCh. 24 - Prob. 9TYCh. 24 - Prob. 10TYCh. 24 - What is the key difference between prezygotic and...Ch. 24 - What are the key differences between gradualism...Ch. 24 - Prob. 3CQCh. 24 - Prob. 1COQCh. 24 - Discuss the type of speciation (allopatric or...
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- CONNECT Why is an understanding of gene regulation in eukaryotes crucial to an understanding of developmental processes? Explain your answerarrow_forwardCompare and contrast the experimental advantages and disadvantages of Drosophila, C. elegans, mammals, and Arabidopsis.arrow_forwardIt seems that developmental genetics boils down to a complex network of gene regulation. Try to draw a structure of this network for Drosophila. How many genes do you think are necessary to complete the developmental network for the fruit fly? How many genes do you think are needed for a network to specify one segment? Do you think it is more difficult to identify genes that are involved in the beginning, middle, or end of this network? Suppose you were trying to identify all of the genes needed for development in a chicken. Knowing what you know about Drosophila development, would you first try to identify genes necessary for early development, or would you begin by identifying genes involved in cell differentiation?arrow_forward
- Discuss the role of homeotic genes in development. Explain what happens to the phenotype of a fruit fly when a gain-of-function mutation in a homeotic gene causes the protein to be expressed in an abnormal region of the embryo. What are the consequences of a loss-of-function mutation in such a gene?arrow_forwardExplain hoxA3 and HoxD3 genes are nearly equivalent yet they play distinct roles in the development of mouse.arrow_forwardAbsence of bicoid mRNA from a Drosophila egg leads to theabsence of anterior larval body parts and mirror-imageduplication of posterior parts. This is evidence that the productof the bicoid gene(A) normally leads to formation of head structures.(B) normally leads to formation of tail structures.(C) is transcribed in the early embryo.(D) is a protein present in all head structures.arrow_forward
- Discuss the role of par genes in generating anterior/posterior polarity in the C. elegans embryo.arrow_forwardDescribe the role of coordinate genes, gap genes, pair rule genes, segment polarity genes, and homeotic genes in Drosophila development.arrow_forwardYou have identified a Drosophila gene that is expressed exclusively in the odd-numbered "stripes" in the cellular blastoderm. Assuming that this gene is not redundant, what would be the most likely phenotype cause by a loss-of-function mutation in this gene? an embryo missing odd numbered segments an adult fly with a second pair of wings instead of halteres an embryo with two anterior ends an embryo missing even-numbered segments an embryo missing larval segments 3-10arrow_forward
- Briefly explain the transcriptional regulation of mammalian gene expression? Please explain at your own words.arrow_forwardWhat is positional information? Discuss three different ways that cells obtain positional information. Which of these three ways do you think is the most important for the formation of a segmented body pattern in Drosophila?arrow_forwardYou are studying Hox genes in crane flies (Leptotarsus testaceus). The cranefly genome is sequenced, and in craneflies. Using your understanding of Hox genes, design an experiment testing where the homolog of the EVE gene is expressed in cranefly embryos. you have access to this sequence. You are interested in studying the EVE genearrow_forward
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