Biology (MindTap Course List)
11th Edition
ISBN: 9781337392938
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Chapter 17, Problem 13TYU
CONNECT Why is an understanding of gene regulation in eukaryotes crucial to an understanding of developmental processes? Explain your answer
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Why is an understanding of gene regulation in eukaryotes crucial to an understanding of developmental processes? Explain your answer
It seems that developmental genetics boils down to a complex network of gene regulation. Try to draw a structure of this network for Drosophila. How many genes do you think are necessary to complete the developmental network for the fruit fly? How many genes do you think are needed for a network to specify one segment? Do you think it is more difficult to identify genes that are involved in the beginning, middle, or end of this network? Suppose you were trying to identify all of the genes needed for development in a chicken. Knowing what you know about Drosophila development, would you first try to identify genes necessary for early development, or would you begin by identifying genes involved in cell differentiation?
Antibiotics such as chloramphenicol, tetracycline, and erythromycin inhibit protein synthesis in bacteria, but have no effect on the synthesis of proteins encoded by eukaryotic nuclear genes. Cycloheximide inhibits the synthesis of proteins encoded by nuclear genes, but has no effect on bacterial protein synthesis. How might these compounds be used to determine which proteins are encoded by mitochondrial and chloroplastgenomes?CHALLENGE QUESTI
Chapter 17 Solutions
Biology (MindTap Course List)
Ch. 17.1 - Prob. 1LOCh. 17.1 - Describe the classic experiments of Steward,...Ch. 17.1 - Define stem cells, distinguish between embryonic...Ch. 17.1 - What lines of evidence support the principle of...Ch. 17.1 - Prob. 2CCh. 17.1 - What does the ability to produce iPSCs tell...Ch. 17.2 - Prob. 4LOCh. 17.2 - Prob. 5LOCh. 17.2 - Prob. 6LOCh. 17.2 - Prob. 7LO
Ch. 17.2 - Prob. 1CCh. 17.2 - Prob. 2CCh. 17.2 - Prob. 3CCh. 17.2 - Prob. 4CCh. 17.3 - Prob. 8LOCh. 17.3 - Prob. 1CCh. 17.3 - Prob. 2CCh. 17 - Prob. 1TYUCh. 17 - Prob. 2TYUCh. 17 - The anteriorposterior axis of a Drosophila embryo...Ch. 17 - Prob. 4TYUCh. 17 - Homeobox genes (a) are found in fruit flies but no...Ch. 17 - Prob. 6TYUCh. 17 - Prob. 7TYUCh. 17 - Which of the following statements about cancer is...Ch. 17 - Proto-oncogenes code for (a) morphogens (b)...Ch. 17 - Prob. 10TYUCh. 17 - Prob. 11TYUCh. 17 - Prob. 12TYUCh. 17 - CONNECT Why is an understanding of gene regulation...Ch. 17 - What is the reason that scientists study...Ch. 17 - Prob. 15TYUCh. 17 - Prob. 16TYUCh. 17 - EVOLUTION LINK What is the common ground between...Ch. 17 - INTERPRET DATA Flower parts are arranged in four...
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- One of the main questions in the field of developmental biology is how cell differentiation works at a molecular level, If vou are a student studving the process of cell differentiation, what would you be studying? Select all correct answers. Whether cells in one species can be transplanted into another species. A. How cells undergo changes in shape, division, and migration to give tissues and organs their three dimensional form. The oxygen carrying capacity of blood from different species. How cells become different from each other and carry out distinct functions due to differential gene expression. OD. Whether certain genes are oncogenes or tumor suppressors in human cancers. E. How muscle progenitor cells undergo changes to become skeletal muscle cells. F.arrow_forwardprovide one example from the Drosophila AP toolkit for "Toolkit genes can be classified according to the phenotypes caused by their mutation. Similar mutant phenotypes often reflect genes that function in a single developmental pathway. Distinct pathways exist for the generation of body axes, for example, and for the formation and identity of fields."arrow_forwardAnother way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes? A. Nanos mRNA injected into the anterior end of an oocyte B. Antp protein injected into the posterior end of an embryo C. Toll mRNA injected into the dorsal side of an early embryoarrow_forward
- Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network? (c) Are genetic networks likely to specify developmental processes in general? Explain fully and provide an example.arrow_forwardDominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network?arrow_forward5. This diagram illustrates regulation of the Pitx-1 gene, which is expressed in various cell types • during certain stages of animal embryonic development. Answer the questions that follow: Promoter Coding Region Pelvis Olfactory Jaw Regulatory Segments ("Switches") a. Which portion of this sequence gets transcribed and translated into a protein? b. Which portion of this sequence underwent a deletion mutation in certain species of freshwater stickleback fish? Did that mutation have an impact on the amino acid sequence of the protein, when it was expressed? С. d. If this switch underwent the same mutation in a turtle embryo, how would the turtle's phenotype be impacted? е. Would this phenotypic change in the turtle likely be adaptive? Briefly explain.arrow_forward
- You have generated a new induced pluripotent stem (iPS) cell line. How would you test for the properties of this cell line to ensure it is similar to the previous iPS cells that Yamanaka and colleagues generated? All of the above RNA-seq to show that the transcriptome is similar to embryonic stem cells Generate a chimera and determine if the cell contributes to endoderm, mesoderm and ectoderm ChIP-qPCR analysis to show active histone marks at promoters of pluripotency genes Prolonged culture of cells to show ability to continually dividearrow_forwardConcept test: Please discuss thoroughly. The easily observed external structures in insects, such as different pairs of legs, antennae, and wings form from imaginal discs. a.) How is the identity of the different Drosophila imaginal discs established in the embryo—for example, how is it determined whether a disc will form a wing, a leg, or some other structure? b.) Dominant mutants in the gene Antennapedia result in fore legs forming in the location where antennae are expected. How does this mutant phenotype illustrate your response to Part a?arrow_forwardExplain hoxA3 and HoxD3 genes are nearly equivalent yet they play distinct roles in the development of mouse.arrow_forward
- Briefly explain the transcriptional regulation of mammalian gene expression? Please explain at your own words.arrow_forwardDiscuss the role of par genes in generating anterior/posterior polarity in the C. elegans embryo.arrow_forwardConcerning the Tools of Genetics Box Analysis ofCell-Cycle Mutants in Yeast:a. Describe how you would use replica plating ofmutagenized, haploid yeast cells to identifytemperature-sensitive (ts) mutations in essentialgenes needed for yeast growth and survival.b. Among the many ts mutations you found in part(a), how would you distinguish mutations in genesneeded for cell-cycle progression from those ingenes needed for other aspects of the life of yeasts?c. If you had a large collection of yeast cell-cyclemutants, how would you determine which of themutations are in the same gene and which are indifferent genes?arrow_forward
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