Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Textbook Question
Chapter 24, Problem 24.7PS
Role of Cyclin-Dependent Protein Kinases. Based on your understanding of the regulation of the eukaryotic cell cycle, how could you explain each of the following experimental observations?
- (a) When mitotic Cdk-cyclin is injected into cells that have just emerged from S phase, chromosome condensation and nuclear envelope breakdown occur immediately, rather than after the normal G2 delay of several hours.
- (b) When an abnormal, indestructible form of mitotic cyclin is introduced into cells, they enter into mitosis but cannot emerge from it and reenter G1 phase.
- (c) Mutations that inactivate the main protein phosphatase used to catalyze protein dephosphorylations cause a long delay in the reconstruction of the nuclear envelope that normally takes place at the end of mitosis.
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Chapter 24 Solutions
Becker's World of the Cell (9th Edition)
Ch. 24 - Prob. 1QCh. 24 - Which DNA sequences are more alike: a pair of...Ch. 24 - Suppose you treat rapidly dividing tissue culture...Ch. 24 - Cyclin D is part of the G1 Cdk-cyclin complex....Ch. 24 - Both EGF (a mitogen) and TGF (when acting as an...Ch. 24 - A knockout mouse has been produced using the...Ch. 24 - Cell Cycle Phases. Indicate whether each of the...Ch. 24 - QUANTITATIVE The Mitotic Index and the Cell Cycle....Ch. 24 - Chromosome Movement in Mitosis. It is possible to...Ch. 24 - Cytokinesis. Predict what will happen in each of...
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- Rb is a negative regulator that blocks the cell cycle at the G1 checkpoint until the cell achieves a requisite size. What molecular mechanism does Rb employ to halt the cell cycle?arrow_forwardDescribe at least two Cdk regulation check points during the cell cycle, Describe how that Step is regulate moluculary and what would happen if that step did not happen correctlyarrow_forwardChanges in the activity of a variety of Cdks are essential for accurate progression through the cell cycle, and yet the levels of Cdk expression are fairly constant during the cell cycle. Briefly describe three mechanisms by which the activity of Cdks is regulated.arrow_forward
- Define Explain the role of CDK inhibitors. If cyclin-CDK com-plexes are necessary to allow regulated progression through the eukaryotic cell cycle, what would be the physiologicalrationale for CDK inhibitors?arrow_forwardWhat cellular mechanism(s) ensure that passage through the cell cycle is unidirectional and irreversible? What mo-lecular machinery underlies these mechanism(s)?arrow_forwardWhat is the effect of having fluctuating cyclin levels throughout the cell cycle, while the levels of its corresponding cyclin dependent kinase stay relatively constant? Explain.arrow_forward
- Drug A323 inhibits the activity of the cyclin-dependent kinase (CDK) - G1 cyclin complex. Consider possible effects of the drug on the cell cycle of normal and malignant cells. Predict what is likely to happen if the drug is added to the cell types described in A). Motivate your answers and describe the role of cycle-regulatory pathways that are relevant with respect to the action. of drug A323. A) Carcinoma cells in which both allels of the Rb gene carries loss of function mutation.arrow_forwardQuestion 8 Review Concept 12.3 Molecular Mechanism of Cell Cycle Regulation. Match the term and its description. Each term can only be used once. This is a cyclin-Cdk complex that triggers a cell's passage [Choose) past the checkpoint G2 into the M phase. This protein rises and falls with changes in concentration [ Choose ) inside of a cell. It binds with a kinase to produce MPF.arrow_forwardWhat composed of a regulatory cyclin subunit and a catalytic cyclin-dependent kinase (CDK) sub-unit, drive the progression of a cell through the cell cycle.arrow_forward
- Fighting Cancer by Disrupting Mitosis Scientists have identified a number of toxins that disrupt mitosis. These toxins can be used in many different ways – some of them are used during scientific research to arrest the cell cycle at specific points so that the cells can be studied. Others have clinical applications as chemotherapeutic drugs that are useful in the treatment of cancer, as well as other types of disease. Study the list of toxins below, and use the information provided and your understanding of mitosis to answer the questions below. Note: some of these drugs are currently approved for clinical use, while others are still in development. For the purposes of this exercise, assume that all of them are available for use. Drug How it affects mitosis Status of drug Vincristine Prevents polymerization of tubulin Approved Paclitaxel Prevents depolymerization of tubulin and can result in multipolar spindle formation Approved Flavopiridol Blocks Cdk-1. Cdk-1 is a kinase that helps…arrow_forward(46) A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies show that the normal p5x molecule binds to DNA, and neoplastic cells accumulate in the G0 phase of the cell cycle. In contrast, the mutated form of p5x does not bin d to DNA. These finding are most characteristics of which of the following? (A) Growht factor receptors (B) GTP-binding protein (C) Nonreceptor tyrosine kinases (D) Oncogene proteins (E) Tumor suppressor gene proteinsarrow_forwardExplain the role of CDK inhibitors. If cyclin-CDK complexes are necessary to allow regulated progression through the eukaryotic cell cycle, what would be the physiological rationale for CDK inhibitors?arrow_forward
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