Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Textbook Question
Chapter 24, Problem 24.2CC
Suppose you treat rapidly dividing tissue culture cells with blebbistatin, which is a potent inhibitor of nonmuscle myosin II. What effects do you predict on mitosis and cytokinesis, and why?
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Fighting Cancer by Disrupting Mitosis
Scientists have identified a number of toxins that disrupt
mitosis. These toxins can be used in many different ways –
some of them are used during scientific research to arrest
the cell cycle at specific points so that the cells can be
studied. Others have clinical applications as
chemotherapeutic drugs that are useful in the treatment of
cancer, as well as other types of disease.
Study the list of toxins below, and use the information
provided and your understanding of mitosis to answer the
questions below.
Note: some of these drugs are currently approved for
clinical use, while others are still in development. For the
purposes of this exercise, assume that all of them are
available for use.
Drug
How it affects mitosis
Status of drug
Vincristine Prevents polymerization of tubulin
Approved
Paclitaxel
Prevents depolymerization of tubulin and can
result in multipolar spindle formation
Approved
Flavopiridol Blocks Cdk-1. Cdk-1 is a kinase that helps…
Chapter 24 Solutions
Becker's World of the Cell (9th Edition)
Ch. 24 - Prob. 1QCh. 24 - Which DNA sequences are more alike: a pair of...Ch. 24 - Suppose you treat rapidly dividing tissue culture...Ch. 24 - Cyclin D is part of the G1 Cdk-cyclin complex....Ch. 24 - Both EGF (a mitogen) and TGF (when acting as an...Ch. 24 - A knockout mouse has been produced using the...Ch. 24 - Cell Cycle Phases. Indicate whether each of the...Ch. 24 - QUANTITATIVE The Mitotic Index and the Cell Cycle....Ch. 24 - Chromosome Movement in Mitosis. It is possible to...Ch. 24 - Cytokinesis. Predict what will happen in each of...
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- You are growing up myoblasts, C2C12 cells, to use in a myogenic study. You are using T-150 flasks with a culture area of 150 cm^2 and when confluent contains 2 x 10^7 cells. Question: You seed a culture at 8 am on Monday with 5 x 10^5 cells. Assume all survive, a generation time of 18 hours and all cells are actively dividing. When would you expect them to be confluent? A) 7:24 AM on Saturday B) 8 pm on Tuesday C) 8 am on Tuesday D) 9 pm on Thursday E) 12:48 pm on Wednesday F) They won't grow that longarrow_forwardWhich of the following changes to the microtubule binding protein, Tau, commonly occurs in Alzheimerâ s and other neurodegenerative diseases? A Tau is hypo-phosphorylated and does not bind to microtubules to destabilize them. B Tau levels are so low in the cell that they only bind to some microtubules. C Tau is hyper-phosphorylated and does not bind to microtubules to stabilize them. D Microtubules are hyper-phosphorylated and do not bind to Tau.arrow_forward11:51 B +$. ← MitosisAndMeiosis.docx AD B C D E F 2. In what stage were most of the onion root tip cells? Does this make sense? 4. What would happen if mitosis were uncontrolled? 3. As a cell grows, what happens to its surface area-to-volume ratio (hint: think of a balloon being blown up)? How does this ratio change with respect to cell division? 5. How accurate were your time predictions for each stage of the cell cycle? & ON 5G A A C 6. Discuss one observation you found interesting while looking at the onion root tip cells. Cell Cycle Division: Mitosis Beads Dia ר Dronhaco EXPERIMENT 2: FOLLOWING CHROMOSOMAL DNA MOVEMENT THROUGH MITOSIS PAGE 5/... OeScience Labs, 2016arrow_forward
- Non-canonical Hedgehog signaling results in actin cytoskeleton rearrangements, leading to cellmovement and changes in cell shape. Describe how changes to the actin cytoskeleton lead to cellmovement and changes in cell shape.You do not need to draw out the signaling pathway again (#1b). Your answer should focus onthe changes to the actin cytoskeleton. Drawings will be helpful!arrow_forwardYou are growing up myoblasts, C2C12 cells, to use in a myogenic study. You are using T-150 flasks with a culture area of 150 cm^2 and when confluent contains 2 x 10^7 cells. Question: You seed a culture of squamous epithelial cells at 8 am on Monday with 1.2 x 10^5 cells. The next day at 8 am you harvest the cells. You know from past studies that the generation time is 26 hours for this cell line. How many cells do you predict you should have on hand? A) 1.64 x 10^5 cells B) 4.56 x 10^3 cells C) 5.23 x 10^10 cells D) 1.75 x 10^8 cells E) None of thesearrow_forwardMitotic spindle function relies heavily on microtubule motors. For each of the following motor proteins, predict the effect on spindle formation, function, or both of adding a drug that specifically inhibits only that motor: kinesin-5, kinesin-13, and kinesin-4.arrow_forward
- Although purified actin can assemble reversibly in vitro, various actin-binding proteins regulate the assembly of actin filaments in the cell. Predict the effect on a cell’s actin cytoskeleton if function-blocking antibodies against each of the following were independently microinjected into cells: profilin, thymosin-β4, CapZ, and the Arp2/3 complex.arrow_forwardOverexpression of the Myc protein is a common feature of many types of cancer cells, contributing to their excessive cell growth and proliferation. By contrast, when Myc is overexpressed in most normal cells, the result is not excessive proliferation, but cell-cycle arrest or apoptosis.Which one of the following statements provides the most likely explanation for why overexpression of Myc can have such different outcomes in normal cells and in cancer cells? A. Normal cells contain checks and balances that prevent Myc-induced proliferation. B. In normal cells, Myc protein acts as a mediator in cell-cycle arrest and apoptosis. C. The target protein for Myc-induced proliferation is missing from most normal cells. D. In normal cells, when Myc is overexpressed, the excess Myc protein precipitates.arrow_forwardGiven the effect of myosin heavy chain phosphorylation on myosin II assembly/disassembly, why might it make sense to find this kinase near the contractile ring as the process of cell division is concluding?arrow_forward
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