Anatomy and Physiology
9th Edition
ISBN: 9781260256000
Author: SALADIN
Publisher: MCG
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Chapter 23.5, Problem 15BYGO
Summary Introduction
Introduction:
Excreting the
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The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached)
a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous?
b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter?
d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?
Define countercurrent multiplier
Describe Countercurrent Multiplier System?
Chapter 23 Solutions
Anatomy and Physiology
Ch. 23.1 - State at least four functions of the kidneys other...Ch. 23.1 - Prob. 2BYGOCh. 23.1 - Prob. 3BYGOCh. 23.1 - Prob. 1AYLOCh. 23.1 - Prob. 2AYLOCh. 23.1 - Prob. 3AYLOCh. 23.1 - Blood urea nitrogen, azotemia, and uremia, and the...Ch. 23.1 - Prob. 5AYLOCh. 23.2 - Prob. 4BYGOCh. 23.2 - Prob. 5BYGO
Ch. 23.2 - Prob. 6BYGOCh. 23.2 - Prob. 1AYLOCh. 23.2 - Prob. 2AYLOCh. 23.2 - Three layers of tissue that surround and...Ch. 23.2 - Prob. 4AYLOCh. 23.2 - Prob. 5AYLOCh. 23.2 - Prob. 6AYLOCh. 23.2 - Prob. 7AYLOCh. 23.2 - Prob. 8AYLOCh. 23.2 - Prob. 9AYLOCh. 23.2 - Prob. 10AYLOCh. 23.2 - Prob. 11AYLOCh. 23.2 - Prob. 12AYLOCh. 23.3 - Prob. 7BYGOCh. 23.3 - Prob. 8BYGOCh. 23.3 - Prob. 9BYGOCh. 23.3 - Prob. 10BYGOCh. 23.3 - Prob. 1AYLOCh. 23.3 - Prob. 2AYLOCh. 23.3 - Prob. 3AYLOCh. 23.3 - Prob. 4AYLOCh. 23.3 - Prob. 5AYLOCh. 23.3 - Prob. 6AYLOCh. 23.3 - How the myogenic mechanism of renal autoregulation...Ch. 23.3 - Structure and function of the juxtaglomerular...Ch. 23.3 - Prob. 9AYLOCh. 23.3 - Prob. 10AYLOCh. 23.3 - Prob. 11AYLOCh. 23.4 - The reabsorption of water, Cl-, and glucose by the...Ch. 23.4 - Prob. 12BYGOCh. 23.4 - Prob. 13BYGOCh. 23.4 - Prob. 1AYLOCh. 23.4 - Prob. 2AYLOCh. 23.4 - Prob. 3AYLOCh. 23.4 - Prob. 4AYLOCh. 23.4 - Prob. 5AYLOCh. 23.4 - Prob. 6AYLOCh. 23.4 - Prob. 7AYLOCh. 23.5 - Prob. 14BYGOCh. 23.5 - Prob. 15BYGOCh. 23.5 - Prob. 16BYGOCh. 23.5 - Prob. 1AYLOCh. 23.5 - Prob. 2AYLOCh. 23.5 - Prob. 3AYLOCh. 23.5 - Function of the countercurrent multiplier and how...Ch. 23.5 - Prob. 5AYLOCh. 23.6 - Prob. 17BYGOCh. 23.6 - Prob. 18BYGOCh. 23.6 - Prob. 19BYGOCh. 23.6 - Prob. 20BYGOCh. 23.6 - Prob. 1AYLOCh. 23.6 - Prob. 2AYLOCh. 23.6 - Prob. 3AYLOCh. 23.6 - Prob. 4AYLOCh. 23.6 - Prob. 5AYLOCh. 23.6 - Prob. 6AYLOCh. 23.6 - Prob. 7AYLOCh. 23.6 - Prob. 8AYLOCh. 23.7 - Prob. 21BYGOCh. 23.7 - Prob. 22BYGOCh. 23.7 - Prob. 23BYGOCh. 23.7 - The route and mechanism of urine transport from...Ch. 23.7 - Prob. 2AYLOCh. 23.7 - Prob. 3AYLOCh. 23.7 - Anatomy of the male urethra, its three segments,...Ch. 23.7 - The mechanism of the spinal micturition reflex and...Ch. 23.7 - Prob. 6AYLOCh. 23 - Prob. 1TYRCh. 23 - The compact ball of capillaries in a nephron is...Ch. 23 - Prob. 3TYRCh. 23 - Prob. 4TYRCh. 23 - Most sodium is reabsorbed from the glomerular...Ch. 23 - Prob. 6TYRCh. 23 - Prob. 7TYRCh. 23 - Prob. 8TYRCh. 23 - Beavers have relatively little need to conserve...Ch. 23 - Prob. 10TYRCh. 23 - Prob. 11TYRCh. 23 - _______ is the ability of a nephron to adjust its...Ch. 23 - The two ureters and the urethra form the...Ch. 23 - The _______ is a group of epithelial cells of the...Ch. 23 - To enter the capsular space, filtrate must pass...Ch. 23 - Glycosuria occurs if the rate of glomerular...Ch. 23 - Prob. 17TYRCh. 23 - Prob. 18TYRCh. 23 - Prob. 19TYRCh. 23 - Prob. 20TYRCh. 23 - Prob. 1BYMVCh. 23 - Prob. 2BYMVCh. 23 - Prob. 3BYMVCh. 23 - Prob. 4BYMVCh. 23 - Prob. 5BYMVCh. 23 - Prob. 6BYMVCh. 23 - Prob. 7BYMVCh. 23 - Prob. 8BYMVCh. 23 - pyelo-Ch. 23 - Prob. 10BYMVCh. 23 - Prob. 1WWTSCh. 23 - Prob. 2WWTSCh. 23 - Prob. 3WWTSCh. 23 - Tight junctions prevent material from leaking...Ch. 23 - Prob. 5WWTSCh. 23 - Prob. 6WWTSCh. 23 - Prob. 7WWTSCh. 23 - The minimum osmolarity of urine is 300 mOsm/L,...Ch. 23 - Prob. 9WWTSCh. 23 - Prob. 10WWTSCh. 23 - Prob. 1TYCCh. 23 - Prob. 2TYCCh. 23 - Prob. 3TYCCh. 23 - Drugs called renin inhibitors are used to treat...Ch. 23 - Prob. 5TYC
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