Concept explainers
The glycine cleavage system is a group of four enzymes that together catalyze the following reaction:
Use the following information to determine the sequence of reactions carried out by the glycine cleavage system:
a. The first enzyme is a PLP-requiring decarboxylase.
b. The second enzyme is aminomethyltransferase. This enzyme has a lipoate coenzyme.
c. The third enzyme synthesizes N5,N10-methylene-THF and also forms +NH4.
d. The fourth enzyme is an FAD-requiring enzyme.
e. The cleavage system also requires NAD+.
Learn your wayIncludes step-by-step video
Chapter 23 Solutions
Organic Chemistry (8th Edition)
Additional Science Textbook Solutions
Essential Organic Chemistry (3rd Edition)
Chemistry: A Molecular Approach
Chemistry: The Central Science (14th Edition)
Chemistry & Chemical Reactivity
Chemistry: A Molecular Approach (4th Edition)
- Describe the difference between graphs showing temperature versus reaction rate for an enzyme-catalyzed reaction and an uncatalyzed reaction.arrow_forwardThe human body has an average pH of about 7 and a temperature of about 37C. Use graphs to illustrate enzyme activity in the human body as a function of the following: a. Substrate concentration b. Enzyme concentration c. pH include pH optimum value d. Temperature include temperature optimum valuearrow_forwardMatch the following enzymes and substrates: Enzyme Substrate a. sucrase b. amylase c. lactase d. maltase e. arginase maltose amylose sucrose arginine lactosearrow_forward
- What is the general role of enzymes in the human body?arrow_forwardBased on the graphical information in Problem 21-41 about enzymes A and B indicate whether the enzyme activity of enzyme B increases or decreases when the following changes in reaction conditions are made. a. pH decreases from 7.6 to 7.2 b. pH increases from 7.2 to 7.4 c. temperature decreases from 37.8C to 37.6C d. temperature increases from 38.2C to 38.4Carrow_forwardThe first step of the metabolic process known as glycolysis is the conversion of glucose to glucose- 6-phosphate. This process has a positive value for rG' Glucose + Pi Glucose-6-phosphate + H2O rG' = +13.8 kJ/mol-rxn This reaction is coupled to the hydrolysis of ATP ATP + H2O ADP + Pi rG' = -30.5 kJ/mol-rxn What is the sum of these two equations and the value of rG' for the coupled reaction? Is the coupled reaction product-favored at equilibrium?arrow_forward
- Chemistry for Today: General, Organic, and Bioche...ChemistryISBN:9781305960060Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. HansenPublisher:Cengage LearningGeneral, Organic, and Biological ChemistryChemistryISBN:9781285853918Author:H. Stephen StokerPublisher:Cengage LearningOrganic And Biological ChemistryChemistryISBN:9781305081079Author:STOKER, H. Stephen (howard Stephen)Publisher:Cengage Learning,
- Chemistry & Chemical ReactivityChemistryISBN:9781337399074Author:John C. Kotz, Paul M. Treichel, John Townsend, David TreichelPublisher:Cengage LearningChemistry & Chemical ReactivityChemistryISBN:9781133949640Author:John C. Kotz, Paul M. Treichel, John Townsend, David TreichelPublisher:Cengage LearningIntroductory Chemistry: An Active Learning Approa...ChemistryISBN:9781305079250Author:Mark S. Cracolice, Ed PetersPublisher:Cengage Learning