Organic Chemistry (8th Edition)
8th Edition
ISBN: 9780134042282
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Question
Chapter 23.3, Problem 8P
Interpretation Introduction
Interpretation:
The structure should be drawn for the decarboxylation of the pyruvate –TPP intermediate and the decarboxylation of a Beta – keto group and then similarity between these two structures has to be shown.
Concept introduction:
Thiamine pyrophosphate (TPP) is the coenzyme required by enzymes that catalyse the transfer of an acyl group.
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Chapter 23 Solutions
Organic Chemistry (8th Edition)
Ch. 23.1 - Prob. 2PCh. 23.1 - Prob. 3PCh. 23.2 - How many conjugated double bonds are there in a....Ch. 23.2 - Instead of adding to the 4a position and...Ch. 23.2 - Prob. 7PCh. 23.3 - Prob. 8PCh. 23.3 - Acetolactate synthase is another TPP-requiring...Ch. 23.3 - Acetolactate synthase transfers the acyl group of...Ch. 23.3 - Prob. 12PCh. 23.5 - Which compound is more easily decarboxylated?
Ch. 23.5 - Prob. 14PCh. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - The enzyme that catalyzes the C C bond cleavage...Ch. 23.5 - Propose a mechanism for the ,-elimination reaction...Ch. 23.6 - Ethanolamine ammonia lyase, a coenzyme...Ch. 23.6 - Prob. 20PCh. 23.7 - How do the structure of tetrahydrofolate and...Ch. 23.7 - What is the source of the methyl group in...Ch. 23.8 - Thiols such as ethanethiol and propanethiol can be...Ch. 23 - How does the metal ion in carboxypeptidase A...Ch. 23 - Prob. 24PCh. 23 - Prob. 25PCh. 23 - For each of the following reactions, name both the...Ch. 23 - Prob. 27PCh. 23 - When transaminated, the three branched-chain amino...Ch. 23 - What acyl groups have we seen transferred by...Ch. 23 - Propose a mechanism for the following reaction:Ch. 23 - Draw the products of the following reaction, where...Ch. 23 - When UMP is dissolved in T2O, exchange of T for H...Ch. 23 - Dehydratase is a PLP-requiring enzyme that...Ch. 23 - In addition to the reaction mentioned in Section...Ch. 23 - PLP can catalyze both ,-elimination reactions...Ch. 23 - The glycine cleavage system is a group of four...Ch. 23 - Prob. 37PCh. 23 - FADH2 reduces , -unsaturated thioesters to...
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- In step 7 of fatty-acid biosynthesis (Figure 29-5), dehydration of a -hydroxy thioester occurs to give trans-crotonyl ACP. Is the dehydration a syn elimination or an anti elimination?arrow_forwardDifferentiate between a ketonemia, b ketonuria, c acetone breath, and d ketosis.arrow_forwardDraw the steps for the conversion of a-ketoglutarate to succinyl-CoA.arrow_forward
- The reaction for “activation” of a fatty acid (RCOO−), ATP + CoA + RCOO−⇌ RCOOCoA + AMP + PPi has ΔG°′ = +4.6 kJ · mol−1. What is the thermo dynamic driving force for this reaction?arrow_forwardIf acetylcholine is combined with acetylcholinesterase in a buffer made from 18O-labeled water, where would you expect to find the 18O label in the products?arrow_forwardAcetolactate synthase transfers the acyl group of pyruvate to alpha-ketobutyrate. This is the first step in the biosynthesis of the amino acid isoleucine. Propose a mechanism for this reaction.arrow_forward
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