Organic Chemistry (8th Edition)
8th Edition
ISBN: 9780134042282
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Question
Chapter 23.3, Problem 12P
(a)
Interpretation Introduction
Interpretation:
The acyl group does pyruvate decarboxylase transfer to a proton has to be identified.
(b)
Interpretation Introduction
Interpretation:
The acyl group does pyruvate dehydrogenase complex transfer to coenzyme A has to be identified.
(c)
Interpretation Introduction
Interpretation:
The acyl group does transketolase transfer to ribose-5-P has to be identified.
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What acyl group does pyruvate decarboxylase transfer to a proton? a. What acyl group does the pyruvate dehydrogenase complex transfer to coenzyme A? b. What acyl group does transketolase transfer to ribose-5-P?
The enzyme 6-phosphogluconate dehydrogenase is part of the pentose pathway
for glucose oxidation. What enzyme that is involved in glucose oxidation by the
citric acid cycle has a very similar reaction mechanism to 6-phosphogluconate
dehydrogenase?
A) isocitrate dehydrogenase
B) alpha-ketoglutarate dehydrogenase
C) succinate dehydrogenase
D) malate dehydrogenase
E) pyruvate dehydrogenase
(99+
RATI
a
Question 5.
The biosynthesis of fatty acids involves an enzyme-catalyzed hydrogenation of an
a,ß-unsaturated thioester to the saturated fatty acid intermediate mediated by
NADPH+. However, the reverse oxidation reaction during fatty acid metabolism
requires a different cofactor FAD.
Fatty Acid
Biosynthesis
a) Draw the structure of FAD.
H
flocon
SCOA
H
SR
+ FAD
- FADH₂
hydrogenation
(reduction)
NADPH+, H+
dehydrogenation
(oxidation)
FAD
Fatty Acid
Metabolism
b) Draw a detailed mechanism of the dehydrogenation of fatty acyl-CoA by FAD
(you can abbreviate AD as R).
H
SR
Chapter 23 Solutions
Organic Chemistry (8th Edition)
Ch. 23.1 - Prob. 2PCh. 23.1 - Prob. 3PCh. 23.2 - How many conjugated double bonds are there in a....Ch. 23.2 - Instead of adding to the 4a position and...Ch. 23.2 - Prob. 7PCh. 23.3 - Prob. 8PCh. 23.3 - Acetolactate synthase is another TPP-requiring...Ch. 23.3 - Acetolactate synthase transfers the acyl group of...Ch. 23.3 - Prob. 12PCh. 23.5 - Which compound is more easily decarboxylated?
Ch. 23.5 - Prob. 14PCh. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - The enzyme that catalyzes the C C bond cleavage...Ch. 23.5 - Propose a mechanism for the ,-elimination reaction...Ch. 23.6 - Ethanolamine ammonia lyase, a coenzyme...Ch. 23.6 - Prob. 20PCh. 23.7 - How do the structure of tetrahydrofolate and...Ch. 23.7 - What is the source of the methyl group in...Ch. 23.8 - Thiols such as ethanethiol and propanethiol can be...Ch. 23 - How does the metal ion in carboxypeptidase A...Ch. 23 - Prob. 24PCh. 23 - Prob. 25PCh. 23 - For each of the following reactions, name both the...Ch. 23 - Prob. 27PCh. 23 - When transaminated, the three branched-chain amino...Ch. 23 - What acyl groups have we seen transferred by...Ch. 23 - Propose a mechanism for the following reaction:Ch. 23 - Draw the products of the following reaction, where...Ch. 23 - When UMP is dissolved in T2O, exchange of T for H...Ch. 23 - Dehydratase is a PLP-requiring enzyme that...Ch. 23 - In addition to the reaction mentioned in Section...Ch. 23 - PLP can catalyze both ,-elimination reactions...Ch. 23 - The glycine cleavage system is a group of four...Ch. 23 - Prob. 37PCh. 23 - FADH2 reduces , -unsaturated thioesters to...
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