The compound A in the given synthesis of the analogs of anthracycline antibiotics is to be identified. Concept introduction: The reaction that involves the rearrangement of the esters of phenol into a hydroxyl aryl ketone with the use of Lewis acid catalyst is called as Fries rearrangement reaction. The relocation of the phenol ester acyl group to the aryl ring takes place in this type of reaction.

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 18P

Interpretation Introduction

Interpretation: The compound A in the given synthesis of the analogs of anthracycline antibiotics is to be identified.

Concept introduction:

The reaction that involves the rearrangement of the esters of phenol into a hydroxyl aryl ketone with the use of Lewis acid catalyst is called as Fries rearrangement reaction.

The relocation of the phenol ester acyl group to the aryl ring takes place in this type of reaction.

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The following questions concern ethyl (2-oxocyclohexane)carboxylate.(a) Write a chemical equation showing how you could prepare ethyl (2-oxocyclohexane)-carboxylate by a Dieckmann cyclization.(b) Write a chemical equation showing how you could prepare ethyl (2-oxocyclohexane)-carboxylate by acylation of a ketone.(c) Write structural formulas for the two most stable enol forms of ethyl (2-oxocyclohexane)carboxylate.(d) Write the three most stable resonance contributors to the most stable enolate derived from ethyl (2-oxocyclohexane)carboxylate.(e) Show how you could use ethyl (2-oxocyclohexane)carboxylate to prepare 2-methylcyclohexanone.(f) Give the structure of the product formed on treatment of ethyl (2-oxocyclohexane)-carboxylate with acrolein (H2C=CHCH=O) in ethanol in the presence of sodium ethoxide

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Answer 2

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 18P

Interpretation Introduction

Interpretation: The compound A in the given synthesis of the analogs of anthracycline antibiotics is to be identified.

Concept introduction:

The reaction that involves the rearrangement of the esters of phenol into a hydroxyl aryl ketone with the use of Lewis acid catalyst is called as Fries rearrangement reaction.

The relocation of the phenol ester acyl group to the aryl ring takes place in this type of reaction.

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Answer 3

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 18P

Interpretation Introduction

Interpretation: The compound A in the given synthesis of the analogs of anthracycline antibiotics is to be identified.

Concept introduction:

The reaction that involves the rearrangement of the esters of phenol into a hydroxyl aryl ketone with the use of Lewis acid catalyst is called as Fries rearrangement reaction.

The relocation of the phenol ester acyl group to the aryl ring takes place in this type of reaction.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 18P

Interpretation Introduction