Prescott's Microbiology
11th Edition
ISBN: 9781260211887
Author: WILLEY, Sandman, Wood
Publisher: McGraw Hill
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Chapter 22, Problem 6AL
Summary Introduction
Myxococcus xanthus is a gram-negative bacteria, that comes under the order Myxococcales. Myxococcus xanthus is a rod-shaped, aerobic soil bacterium having gliding motility and a complex life cycle which involves the formation of fruiting bodies and myxospores.
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Recent evidence points towards a global increase in cases of multi drug and total drug resistant forms of Mycobacterium tuberculosis, suggesting that the mycobacterium is becoming resistant to the antibiotic regimen used to treat this infectious disease. New therapies are clearly needed, which may emerge from an improved understanding of the mechanisms by which M. tuberculosis avoids cellular clearance by lysosomes following engulfment in macrophage phagosomes. We now report that one of the common anti-tubercular drug targets, the so-called RND permease multi substrate pumps, is capable of secreting mycolic acids, a form of lipid enriched in these mycobacteria that make up part of the pathogens cell wall, as a way to inhibit phago- lysosome fusion and survive within the host cell. Our findings provide a mechanism that may explain how these cholesterol like mycolic acids may inhibit the lysosomal protein NPC1, a lysosomal cholesterol transporter and the only mammalian member of the RND…
Which of the following would you anticipate would be secreted through the Type III secretion system during infection?
a secondary messenger effector that is unable to cross the host cell membrane, such as the AexT protein that disrupts the host cell cytoskeleton
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a pore-forming cytolytic toxin, such as a hemolysin
not enough information to determine
the AB toxin responsible for the flaccid paralysis associated with botulism
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Chapter 22 Solutions
Prescott's Microbiology
Ch. 22.1 - What would Rhodospirillum rubrum use for carbon...Ch. 22.1 - How are bacterial cysts different from the...Ch. 22.1 - If Caulobacter bacteria were grown in a...Ch. 22.1 - What steps are also found in the TCA cycle? What...Ch. 22.1 - Why do nitrifying microbes possess intracellular...Ch. 22.1 - Prob. 6MICh. 22.1 - Prob. 1CCCh. 22.1 - Prob. 2CCCh. 22.1 - Prob. 3CCCh. 22.1 - Compare and contrast the life cycle of members of...
Ch. 22.1 - Prob. 5CCCh. 22.1 - Prob. 6CCCh. 22.1 - Prob. 7CCCh. 22.1 - Prob. 8CCCh. 22.2 - MICRO INQUIRY Suggest why N. europaea has PTS...Ch. 22.2 - MICRO INQUIRY Identify the reactions that...Ch. 22.2 - Prob. 1CCCh. 22.2 - Prob. 2CCCh. 22.2 - Prob. 3CCCh. 22.2 - How do colorless sulfur bacteria obtain energy by...Ch. 22.2 - Prob. 5CCCh. 22.3 - Prob. 1MICh. 22.3 - Prob. 2MICh. 22.3 - Prob. 3MICh. 22.3 - Prob. 1CCCh. 22.3 - Prob. 2CCCh. 22.3 - Prob. 3CCCh. 22.3 - Prob. 4CCCh. 22.3 - Prob. 5CCCh. 22.3 - Prob. 6CCCh. 22.3 - Prob. 7CCCh. 22.4 - Prob. 1MICh. 22.4 - What general features are common to most...Ch. 22.4 - Prob. 2CCCh. 22.4 - Prob. 3CCCh. 22.4 - Characterize Bdellovibrio spp. and outline the...Ch. 22.4 - Compare the growth of a myxobacterium in...Ch. 22.5 - What property unifies -proteobacteria?Ch. 22.5 - Prob. 2CCCh. 22.5 - Prob. 3CCCh. 22 - Prob. 1RCCh. 22 - Prob. 2RCCh. 22 - Prob. 3RCCh. 22 - Prob. 4RCCh. 22 - Prob. 5RCCh. 22 - Prob. 6RCCh. 22 - Prob. 7RCCh. 22 - Prob. 8RCCh. 22 - Prob. 9RCCh. 22 - Prob. 1ALCh. 22 - Prob. 2ALCh. 22 - Prob. 3ALCh. 22 - Prob. 4ALCh. 22 - Prob. 5ALCh. 22 - Prob. 6ALCh. 22 - Prob. 7ALCh. 22 - Prob. 8ALCh. 22 - Prob. 9AL
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