Concept explainers
(a)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Glycogen phosphorylase is one of the phosphorylase enzymes.
(b)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Phosphorolysis is analogous to hydrolysis.
(c)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Transferases are enzymes that catalyzes the transfer of certain
(d)
Interpretation:
Each item should be matched with its description.
Concept introduction:
a-1,6-glucosidase is a glycogen debranching enzyme which involves in glycogen catabolism.
(e)
Interpretation:
Each item should be matched with its description.
Concept introduction:
The free glucose molecule released from the cleavage of glucosyl residue from glycogen after glycogen phosphorylase activity, has a phosphate group on C-1. This glucose-1-phosphate is not a useful metabolite. So it should be converted to glucose-6-phosphate.
(f)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Phosphorylase kinase is a serine/threonine specific protein kinase.
(g)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Protein kinase A perform several functions like regulation of glycogen, sugar and lipid
(h)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Calmodulin is a calcium binding protein which is found in all eukaryotic cells. Ca2+ is required for the activation of calmodulin.
(i)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Epinephrine is a hormone and also known as adrenaline. It is secreted by adrenal glands and used as a medication for various illnesses.
(j)
Interpretation:
Each item should be matched with its description.
Concept introduction:
Glucagon is secreted in alpha cells in pancreas. It is a peptide hormone. It is considered as the major catabolic hormone in human body.
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Biochemistry
- phosphorylation/dephosphorylation 5. Diagram the cascade that regulates glycogen metabolism. Please use key enzyme names and arrows to show how glycogen phosphorylase and glycogen synthase are inversely activated/deactivated.arrow_forward2A. Red blood cells synthesize and degrade 2,3-bisphosphoglycerate (2,3-BPG) by a detour of the glycolytic pathway, as shown below: glyeeraldehyde 3-phosphate GAP dehydrogenase 1,3-bisphosphoglycerate bisphosphoglycerate mutase ADP phosphoglycerate kinase 2,3-bisphosphoglycerate ATP 3-phosphoglycerate 2,3-bisphosphoglycerate phosphatase phosphoglycerate mutase 2-phosphoglycerate (i) The bisphosphoglycerate mutase/2,3-bisphosphoglcerate phosphatase reaction is catalyzed by a single enzyme, BPGM. At alkaline pH, BPGM favors the mutase activity while at lower pH, BPGM favors the phosphatase reaction. Use this information, along with the Bohr effect, to explain in the space below how red blood cells respond to a metabolic defect where a patient experiences chronic, elevated levels of lactic acid. I (ii) Individuals with red blood cell phosphoglycerate kinase deficiency suffer from moderate hemolytic anemia (a condition where red blood cells self-destruct before their normal lifespan). They…arrow_forwardLong explanations are not needed. Direct answers would suffice. a. In the TCA cycle, succinate dehydrogenase channels electrons directly into the electron transfer chain. I. True II. False b. Glucagon is a hormone that activates glycogenolysis. I. True II. Falsearrow_forward
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- Butch Cassidy and the Sundance Kid. Glutamate dehydrogenase requires which of the following cofactors: a. NAD+/NADP+NAD*/NADP+ b. Pyridoxal phosphate c. Thiamine pyrophosphate d. Biopterinarrow_forwardIn full details. Explain the significance of redox potentials formed by redox pairs in the electron transport chain.arrow_forwardDescribe the impact of phosphorylation of glycogen phosphorylase on its heterotropic regulation. (Don’t need the structural details; focus on the qualitative effects on allostery; be brief and to the point)arrow_forward
- -CHOOSE THE CORRECT LETTER- 1.Which enzymes are required in the breakdown of glycogen?A. glycogen phosphorylase, debranching enzyme, phosphoglucomutaseB.glycogen phosphatase, glucose phosphorylase, pyrophosphataseC. glycogen phosphorylase, branching enzyme, glucose 1-phosphataseD. phosphoglucose isomerase, debranching enzyme, pyrophosphorylase 2.When glycogen is synthesized in both the liver and muscle, all the following are true, EXCEPTA. Glucose 6-phosphate is converted to glucose by a phosphatase.B. Glucose is transferred from UDP-glucose to a growing glycogen molecule by glycogen synthase.C. Phosphoglucomutase converts glucose 6-phosphate to glucose 1-phosphateD.Glucose 1-phosphate is activated by UDP-glucose pyrophosphorylase to,produce UDP-glucose and PPi.arrow_forward1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.arrow_forwardhelp fill in the blanks Glucose is exported from liver cells when [hexokinase IV/glucose 6-phosphatase] and [glycogen synthase/glycogen phosphorylase] are active during [glucagon/insulin] signaling. It is exported through [GLUT1/GLUT2/GLUT4] into the bloodstream.arrow_forward