Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 21, Problem 36P
Interpretation Introduction
Interpretation:
The pathway in addition to the cAMP-induced signal transduction pathway that is used in the liver to maximize glycogen breakdown should be explained.
Concept introduction:
To breakdown the glycogen molecule, it needs epinephrine and glucagon Signal. Epinephrine is hormone
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Nursing question.Please Discuss the biosynthesis of epinephrine. Give one important medical use of epinephrine.?.
1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase,
Write an expression for the reaction velocity.
Inducers and Inhibitors of AEP.
Short peptides such as legumain stabilization and activity modulation (LSAM) domain and αvβ3 integrin could enhance the activity of AEP. LSAM domain known as the prodomain of AEP blocks substrate binding before activation. This prodomain has a helical structure and two independent peptides. One is an activation peptide (AP, K287 to N323), and the other is a LSAM domain. LSAM domain remains even after AP is cleaved and released from protease at neutral pH via electrostatic interaction. AEP without LSAM domain has a lower melting temperature than AEP with LSAM domain [77, 117]. Another short peptide, αvβ3 integrin, can directly interact with AEP, and after forming a complex, the optimal pH for AEP activity is increased from 5.5 to 6.0. It indicates that αvβ3 binding could induce conformational stabilization of AEP accompanied by deprotonated C189. αvβ3 does not directly interact with the AEP active site; however, AEP docks to the αvβ3 RGD-binding site…
Chapter 21 Solutions
Biochemistry
Ch. 21 - Prob. 1PCh. 21 - Prob. 2PCh. 21 - Prob. 3PCh. 21 - Prob. 4PCh. 21 - Prob. 5PCh. 21 - Prob. 6PCh. 21 - Prob. 7PCh. 21 - Prob. 8PCh. 21 - Prob. 9PCh. 21 - Prob. 10P
Ch. 21 - Prob. 11PCh. 21 - Prob. 12PCh. 21 - Prob. 13PCh. 21 - Prob. 14PCh. 21 - Prob. 15PCh. 21 - Prob. 16PCh. 21 - Prob. 17PCh. 21 - Prob. 18PCh. 21 - Prob. 19PCh. 21 - Prob. 20PCh. 21 - Prob. 21PCh. 21 - Prob. 22PCh. 21 - Prob. 23PCh. 21 - Prob. 24PCh. 21 - Prob. 25PCh. 21 - Prob. 26PCh. 21 - Prob. 27PCh. 21 - Prob. 28PCh. 21 - Prob. 29PCh. 21 - Prob. 30PCh. 21 - Prob. 31PCh. 21 - Prob. 32PCh. 21 - Prob. 33PCh. 21 - Prob. 34PCh. 21 - Prob. 35PCh. 21 - Prob. 36PCh. 21 - Prob. 37PCh. 21 - Prob. 38PCh. 21 - Prob. 39PCh. 21 - Prob. 40PCh. 21 - Prob. 41PCh. 21 - Prob. 42PCh. 21 - Prob. 43PCh. 21 - Prob. 44PCh. 21 - Prob. 45PCh. 21 - Prob. 46P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- IDENTIFICATION. One of the B-complex vitamins which is the precursor of Nicotinamide in the coenzyme NAD+. Carrier of the activated amino acids to the ribosomes for incorporation into the growing peptide chain. Molecule that attaches to myosin and actin during muscle contraction.arrow_forwardBIOCHEMISTRY. Could glycerol be used to regenerate the OAA for maintenance of TCA cycle activity? Yes or No? Explain.arrow_forwardAssighment. Create a diagram which illustrates the typical signalling mechanism of action of each of the four common classes of receptor (e.g. kinase-linked receptors etc.) and possible routes of communication (autocrine etc.). Your diagram should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. For each of the examples describe the mechanism of action in the form below. DO NOT use any of the ligand-receptor combinations provide to you in the Learning Materials to date - research and create a diagram for a novel pathway instead!arrow_forward
- Hi, help please. Discuss each method of regulating phosphofructokinase below as indicated by the circle. Discuss 1.) The type of regulation occurring, 2.) What compound or condition performs the regulation, 3.) How/why it influences the enzyme activity.arrow_forwardHelp fill in the blanks Fructose 2,6-bisphosphate allosterically [inhibits/activates] PFK-1 and allosterically [inhibits/activates] FBPase-1. This is how gluconeogenesis and glycolysis are coordinately regulated. By deduction, glucagon should [inhibit/activate] the enzyme that produces fructose 2,6-bisphosphate since glucagon [activates/inhibits] gluconeogenesis.arrow_forwardIn briefly give. What is hepatotoxicity and why is it serious?arrow_forward
- Need help. do explainarrow_forwardUnique explaination. LisT Factors that influence enzymatic activity.arrow_forwardFill in the blanks. Acetaminophen toxicity can occur at high doses in the liver. because ___________ (what type of molecules?) can become saturated and other routes of metabolism take over.Please explain to me what the correct molecule(?) is and why it is correct. I understand that the glucuronidation and sulfation conjugation pathways become saturated, but am not understanding what molecule(s) it is/are that is/are becoming saturated leading to the other routes of metabolism and acetaminophen toxicity.arrow_forward
- disease. As such, a frontline treatment for Type 2 diabetes is the drug metformin, which acts indirectly to inhibit gluconeogenesis in the liver. You are a research biochemist who would like to develop new drugs that act to directly inhibit gluconeogenesis. You have just gained access to a library of thousands of small molecules of unknown activity, and you would like to identify lead compounds that have specific inhibitory activity against steps in the gluconeogenesis pathway. (a) into PEP in order to screen for inhibitors of enzymes specific to gluconeogenesis. Which enzymes do you need to purify, what cofactors and allosteric effectors do they require, and which reactants do you need to add to reconstitute the reactions for the first bypass? Which intermediates and products are generated? Your first approach is to reconstitute the initial set of bypass reactions that convert pyruvate (b) vitro reconstitution? What additional steps and enzymes are required in liver cells but are…arrow_forwardTRUE or FALSE. If false, write the word/s that make(s) the statement incorrect. 1.Since insulin binds to receptors on the cell surface, therefore it is an example of a second messenger. 2. Mg2+ is an important cofactor in replication only.arrow_forwardDraw Gluconeogenesis. Please make sure to state all the enzymes and co-factors for each step of the pathway. note you are responsible for all the enzymes for each step, even though it is not stated on the slide.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. Freeman
Lehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY 
BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON