Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 20, Problem 3DAA
Bacteriophage-Inspired Antibiotics Although bacteriophages have been infecting bacteria for billions of years, no mechanism, has evolved in bacteria to prevent the viruses from lysing the cell walls of their hosts. Now, scientists are targeting the same bacterial wall components that bacteriophages do. The goal is to develop antibiotics that bacteria will be less likely to develop resistance to.
FIGURE 20.22 shows the results of a study to test Epimerox, a new bacteriophage-inspired antibiotic, against Bacillus anthracis, the bacterial species that causes the disease anthrax.
FIGURE 20.22 Effect of Epimerox on the survival of mice with anthrax. Mice were infected with the bacteria B. anthracis. One group of 15 then began receiving a drug-free buffer solution 3 hours later. Another 15 were treated with Epimerox beginning 3 hours after infection. A third group of 15was treated with Epimerox beginning 24 hours after infection.
In studies with Bacillus anthracis cells grown in culture, no Epimerox-resistant cells were observed. Explain why this result is consistent with the scientists' goal for developing this drug.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The figure depicts five stages of the lytic cycle.
*********
Select the statement that describes stage 3 of the lytic cycle,
as shown in the diagram.
The host cell synthesizes cellular proteins to prepare
for lysis.
The host cell incorporates phage DNA into its
own genome.
The host cell replicates the phage DNA.
O The host cell synthesizes proteins that degrade
phage DNA.
1. Precise words:Find the nonspecific terms in the following sentences. Replace the nonspecific choices with more preciseterms or phrases (It is not necessary to change the sentence structure).(i) All OVE mutants showed enhanced iP concentrations.(ii) Plants were kept in the cold overnight.(iii) To provide proof of concept for our hypothesis, we studied a virus in its host cell.(iv) The present paper reports on continuing experiments that were performed to clarify thissurprising effect.(v) The first transition state is a little lower in energy than the second transition state.
2. Simple words:Improve the word choice in the following examples by replacing the underlined terms or phrases withsimpler word choices (do not change the sentence structure).(i) These data substantiate our hypothesis.(ii) The difference in our results compared to those of Reuter et al. (1995) can be accounted forby the fact that different conditions were used.(iii) For the purpose of discussing cell migration we…
Transfer of resistance to a new family of antimicrobial agents from one strain to another s following a genetic mechanisms?
1) Conjugation
2) Transduction
3) Transformation
4) Transposition
5) Recombination
Chapter 20 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 20 - Bacteriophage-Inspired Antibiotics Although...Ch. 20 - Bacteriophage-Inspired Antibiotics Although...Ch. 20 - Bacteriophage-Inspired Antibiotics Although...Ch. 20 - The genome of ___ can be either RNA or DNA. a. a...Ch. 20 - The capsid of a virion consists of ___ . a. DNA b....Ch. 20 - Bacteriophages kill their host quickly by ______ ....Ch. 20 - The genetic material of HIV (a retrovirus) is...Ch. 20 - Prob. 5SQCh. 20 - Prob. 6SQCh. 20 - Prob. 7SQ
Ch. 20 - Bacteria that serve as decomposers are ___ . a....Ch. 20 - Prob. 9SQCh. 20 - Formation of a(n) ___ allows some soil bacteria to...Ch. 20 - _____ in the stomach of a cow release methane. a....Ch. 20 - A plasmid is a circle of ___ . a. RNA b. DNA c....Ch. 20 - Prob. 13SQCh. 20 - Prob. 14SQCh. 20 - Prob. 15SQCh. 20 - Prob. 1CTCh. 20 - Adenoviruses that cause colds do not have a lipid...Ch. 20 - The antibiotic penicillin acts by interfering with...Ch. 20 - Raw red alga of the genus Porphyra is part of a...
Additional Science Textbook Solutions
Find more solutions based on key concepts
To test your knowledge, discuss the following topics with a study partner or in writing ideally from memory. Th...
Human Anatomy
Explain why hyperthermophiles do not cause disease in humans.
Microbiology with Diseases by Taxonomy (5th Edition)
On what molecule does the anticodon appear? Explain the role of this molecule in protein synthesis.
Human Physiology: An Integrated Approach (7th Edition)
Identify each of the following reproductive barriers as prezygotic or postzygotic. a. One lilac species lives o...
Campbell Essential Biology with Physiology (5th Edition)
A student moving out of a dormitory crouches in correct fashion to lift a heavy box of books. What prime movers...
HUMAN ANATOMY
Describe the role and impact of microbes on the earth.
Microbiology Fundamentals: A Clinical Approach - Standalone book
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The properties that all plasmids share are that they1. all carry genes for antimicrobial resistance.2. are self-transmissible to other bacteria.3. always occur in multiple copies in the cells.4. code for non-essential functions.5. replicate in the cells in which they are found.a) 1, 2 b) 2, 3 c) 3, 4 d) 4, 5 e) 1, 5arrow_forwardMatch each antibacterial drug with its primary target. Chloramphenico✓ Choose... Nucleic acid synthesis Fluoroquinolone Cell membrane Cell wall Tetracycline Metabolic pathway Translation Rifampin Aminoglycosides Choose... Macrolide Choose... Penicillin Choose... Sulfonamides Choose... Cephalosporin Choose... Vancomycin Choose... Polymyxin Choose... → ( 4 ( ( ( (arrow_forwardA patient is asked to participate in a trial using a bacteriophage to treat a Streptococcus infection. The patient is worried that she will end up with a viral infection rather than a Streptococcal infection. How would you address her concerns? – discuss the specificity of viral infections. How do they infect host cells, is that a random process?arrow_forward
- What properties make ribavirin an effective antiviral compound? Give an example of a virus and yay is inhibited by ribavirin. Thank you!arrow_forward3) Would mRNA vaccines be as effective against bacteria as they are against viruses? Why or why not? Questions related to SARS-CoV-2 Inhibitor Science Article (Zhang et al.) 1) What is the function of the viral main protease? 2) What is the amino acid recognition sequence that is cleave by this main protease? Indicate where this protease cuts? 3) Would interfering with this protease effect other proteases in human cells? 4) How closely related are the amino acid sequences between SARS-CoV-2 and SARS-CoV? What does this suggest about focusing research on inhibiting this enzyme?arrow_forwardThe ribosome is the target for many important antibiotics. These drugs must discriminate between bacterial and eukaryotic ribosomes to achieve drug specificity and toxicity. For the two common antibiotics below, what is their mechanism of action and why are they more toxic to bacteria than eukaryotes? a) Tetracycline b) Erythromycinarrow_forward
- You are studying your favorite (hypothetical) bacteriophage named M277. It infects E. coli and stays dormant within the bacterial cell. How does a phage become dormant within a cell? Generally, describe the steps of infection by phage in this scenarioarrow_forwardSome retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.arrow_forwardPut the following stages of a lytic replication cycle in order, from earliest to latest stages: I. Synthesis, II. Assembly. II. Attachment, IV. Release, V. Entry O 1) III, II, V, I, IV 2) I, II, III, V, IV O 3) v, III, II, IV, I O4) 1, III, V, II, Iv O 5) III, V, I, II, IVarrow_forward
- A4-month-old infant had been running a moderate fever for36 hours, and a nervous mother made a call to her pediatrician.Examination and tests revealed no outward signs of infectionor cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother wasnot placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues. Question How should the pediatrician balance his ethical responsibility to provide effective treatment to the present patient with…arrow_forwardDescribe the process of replication of a Lytic phage and a Lysogenic phage. In your answer you must include the different steps of the replication process as well as appropriate terms used to name these steps of the process. Compare and contrast both methods of replication and indicate the relevance of lysogenic cycle of phage replication to bacterial antibiotic resistance.arrow_forwardA4-month-old infant had been running a moderate fever for36 hours, and a nervous mother made a call to her pediatrician.Examination and tests revealed no outward signs of infectionor cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother wasnot placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues. Question: If the infant was given antibiotics, how might this have contributed to the production of resistant bacteria?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
What Is A Virus ? ; Author: Peekaboo Kidz;https://www.youtube.com/watch?v=YS7vsBgWszI;License: Standard YouTube License, CC-BY