Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 20, Problem 20.8PS

(a)

Summary Introduction

To explain: The way in which testosterone and hydrocortisone are able to selectively influence the production of two different proteins in the same tissue.

Introduction: Steroid hormones are hormones which increase the expression of specific genes in selected target cell types. Testosterone is an example of a steroid hormone. It increases the production of the protein α2-microglobulin in the liver. Hydrocortisone is also an example of a steroid hormone. It increases the production of the enzyme tyrosine aminotransferase in the liver.

(b)

Summary Introduction

To determine: How the treatment of the liver with puromycin or α-amanitin prior to the administration of testosterone or hydrocortisone will affect the actions of testosterone and hydrocortisone.

Introduction: Steroid hormones are hormones which increase the expression of specific genes in selected target cell types. Testosterone is an example of a steroid hormone. It increases the production of the protein α2-microglobulin in the liver. Hydrocortisone is also an example of a steroid hormone. It increases the production of the enzyme tyrosine aminotransferase in the liver.

(c)

Summary Introduction

To determine: The effect of testosterone and hydrocortisone that will be expected in cells containing altered receptors due to a domain-swap experiment.

Introduction: Steroid hormones are hormones which increase the expression of specific genes in selected target cell types. Testosterone is an example of a steroid hormone. It increases the production of the protein α2-microglobulin in the liver. Hydrocortisone is also an example of a steroid hormone. It increases the production of the enzyme tyrosine aminotransferase in the liver.

(d)

Summary Introduction

To determine: The effect that testosterone and hydrocortisone will have in a case where the testosterone response element is substituted for a glucocorticoid response element.

Introduction: Steroid hormones are hormones which increase the expression of specific genes in selected target cell types. Testosterone is an example of a steroid hormone. It increases the production of the protein α2-microglobulin in the liver. Hydrocortisone is also an example of a steroid hormone. It increases the production of the enzyme tyrosine aminotransferase in the liver.

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