BIOLOGY
BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Chapter 19, Problem 6A

What would be the likely result of a mutation of the bcl-2 gene on the level of apoptosis

a. No change

b. A decrease in apoptosis

c. An increase in apoptosis

d. An initial decrease, followed by an increase in apoptosis

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BAX proteins stimulate apoptosis. Mutations in BAX genes can help developing cancers but not necessarily trigger a tumor. This is because a. mutations in BAX do not contribute to tumorigenesis, but BAX can prevent the formation of a tumor b. mutations in BAX may over-stimulate apoptosis c. mutations in BAX contribute to tumorigenesis only with other inhibitors of apoptosis d. mutations in BAX prevent the formation of tumors
Predict the effects of the following mutations on the ability of a cell to undergo apoptosis:a. Mutation in Bad such that it cannot be phosphorylated by protein kinase B (PKB)b. Overexpression of Bcl-2c. Mutation in Bax such that it cannot form homodimersOne common characteristic of cancer cells is a loss of function in the apoptotic pathway. Which of the mutations listed above might you expect to find in some cancer cells?
What would be the effect on the following processes in a cancer cells treated with Drug X. Match the process with the likely effect of the drug. Protein Translation Apoptosis Cell Proliferation Production of new blood vessels A. Inhibited B. Activated
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY