How does the Apoptosis Through Death Receptors pathway work, where it works and why it works. Include a diagram of the steps.

Cancer is a complicated series of diseases characterized by over-proliferation of cells within a tissue. While in some instances the primary tumor is the ultimate cause of death, in many cases the primary tumor metastasizes, or moves, through the lymph system to invade other tissues. The migration of tumor cells requires changes in the adhesion properties of the cell that allow it to move and invade more readily.  There are several molecules involved in cell-to-cell connections and cellular architecture: laminins, matrix metalloproteinases, cadherins, and integrins. While mutations in genes that control the cell cycle or recognize DNA damage are the causes of tumor cell formation, tumor cell spread to other tissues may be caused by mutations in the genes the code for these extracellular proteins. The loss of cellular connections, cellular identification and signaling, and tissue structure may lead to the release of expanding tumor cells into the circulatory and lymphatic systems. Once…

Upon learning about the mechanism of apoptosis, the question asked was; Is cytochrome c being released from mitochondria or is it being expressed by an induced nuclear gene and being produced in the cytosol. Which one of the following observations would provide the best evidence that it was being released from the mitochondria? Bcl2 blocks release of cytochrome c from mitochondria and also inhibits apoptosis Active Fas receptors trigger release of cytochrome c from mitochondria. Extracellular signals that block apoptosis do not produce cytosolic cytochrome c Caspase inhibitors block release of cytochrome c from the mitochondria

Compare and contrast oncogenes versus tumor-suppressorgenes.