BIOLOGY
BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Chapter 19, Problem 4S

Assume you have the factors in hand necessary to reprogram an adult cell, and the factors necessary to induce differentiation to any cell type. How could these be used to replace a specific damaged tissue in a human patient?

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Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Cancer is modeled through the generation of induced pluripotent stem cells. Please explain the questions in detail (Especially 2nd and 3rd question please, thank you):1) why is it important to model such a disease(cancer)?2) what were the key findings after modeling such a disease (cancer)? 3) a drug that has been screened in this disease model (cancer). Explain in detail the main findings.
Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please select a disease (like cancer) that can be modeled through the generation of induced pluripotent stem cells. You can use published literature and explain:1) why is it important to model such a disease?2) what were the key findings after modeling such a disease? 3) a drug that has been screened in this disease model. Explain in detail the main findings.
The best strategy for treating a specific type of human tumor can depend on identifying the type of cell that became cancerous to give rise to the tumor. For some tumors that have colonized a distant location (metastasized), identifying the parental cell type can be difficult. Because the type of IF protein expressed is cell-type-specific, using monoclonal antibodies that react with only one type of IF protein can help in this identification. What IF proteins would you produce monoclonal antibodies against to identify (a) a sarcoma of muscle cell origin, (b) an epithelial cell carcinoma, and (c) an astrocytoma (glial cell tumor)?
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Cell Differentiation | Genetics | Biology | FuseSchool; Author: FuseSchool - Global Education;https://www.youtube.com/watch?v=gwAz_BtVuLA;License: Standard YouTube License, CC-BY