Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 18, Problem 7TY
Summary Introduction
Introduction: The epigenetic changes refer to the changes that alter the gene expression but do not alter the sequence of DNA. The epigenetic changes can be caused as a result of environmental factors also and can result in the development of many diseases and disorders.
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Which of the following accurately compares tumor suppressor genes and proto-oncogenes?
A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells.
B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer.
C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells.
D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.
The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene or a tumor-suppressor gene. Several years later, researchers showed that both p53 alleles are inactivated in some mouse cancers. This evidence suggests
A. the p53 gene is an oncogene because inactivated alleles would produce mutated signal transduction proteins that would result in stimulating cell division.
B. the p53 gene is an oncogene because the cell would overproduce transcription factors to compensate for the inactive alleles, resulting in increased cell division.
C. the p53 gene is a tumor-suppressor gene because inactivated alleles indicate a loss of protein function which allowed the cancer to develop
D. the p53 gene is a tumor-suppressor gene because the cell would produce too few transcription factors for gene activation, resulting in decreased cell division.
Which of the following steps are correct about multistep tumorigenesis (select all that apply)?
A.
Mutations in progenitor cells are more likely to develop a neoplastic state compared to mutations in stem cells
B.
Driver mutations give a cell clone a proliferative advanage
C.
The rate of mutation /genetic change is constant during tumor progression
D.
Nutrition/diet may effect rate of tumorigenesis
E.
All cells within a tumor are biologically equivalent and equally capable of high levels proliferation
Chapter 18 Solutions
Biology
Ch. 18.2 - Prob. 1CCCh. 18.3 - Prob. 1CCCh. 18.3 - Prob. 1CSCh. 18.5 - Prob. 1CSCh. 18.5 - Prob. 1CCCh. 18.6 - Prob. 1EQCh. 18.6 - Prob. 2EQCh. 18.6 - Prob. 3EQCh. 18.6 - Prob. 1CCCh. 18.6 - Prob. 2CC
Ch. 18 - Which of the following is an example of an...Ch. 18 - Prob. 2TYCh. 18 - A female mouse that is Igf2 Igf2 is crossed to a...Ch. 18 - Prob. 4TYCh. 18 - Prob. 5TYCh. 18 - Prob. 6TYCh. 18 - Prob. 7TYCh. 18 - Prob. 8TYCh. 18 - Based on the ideas proposed by Morgan, which of...Ch. 18 - Extranuclear inheritance occurs because a. certain...Ch. 18 - Define epigenetics. Are all epigenetic changes...Ch. 18 - What is a Barr body? How is its structure...Ch. 18 - Core Concept: Information A core concept of...Ch. 18 - Prob. 1COQCh. 18 - Mendel studied seven traits in garden pea plants,...
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- RASL11A gene is a tumor suppressor gene associated with spontaneous tumor shrinkage in Tasmanian Devils. In those tumors that shrink, the expression of RASL11A is: Group of answer choices a. upregulated compared to the expression in tumors that proliferate. b. downregulated compared to the expression in tumors that proliferate. c. the same as in those tumors the expression in tumors that proliferate. While studying tumor cells, you notice that the histones of a particular chromosome have more acetyl groups bound to them in tumor cells, compared to the same chromosome in healthy cells. What would you expect for the amount of proteins encoded by genes on that chromosome in tumor cells compared to healthy cells? Group of answer choices a. Higher in tumor cells b. Lower in tumor cells c. Similar in tumor and healthy cellsarrow_forwardWhich of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogenearrow_forwardWhich of the following is NOT a way in which proto-oncogenes can change to become genes that induce cancer? Group of answer choices a. changes in a control element (enhancer) to increase transcription b. gene amplification c. changes in DNA sequence to produce a product that degrades rapidly d. movement of the gene adjacent to a different control element to increase transcription e. changes in DNA sequence to produce a product that isarrow_forward
- Which of the following statements are correct about cytoplasmic signaling in cancer cells? Multiple answers. A. Only minor modifications of cell control machinery are required for normal cells to become highly proliferating cancer cells B. Immediate early genes are induced in the presence of protein synthesis inhibitors C. Many immediate -early genes are oncogenes D. Delayed early genes are highly expressed in the presence of protein synthesis inhibitors E. Delayed early genes are highly expressed in normal cells in the absence of growth factorsarrow_forwardWhich of the following statements about cancer is correct? A. Cancer stem cells can make tumors resistant to chemotherapy. B. Intra-tumoral heterogeneity makes it easier to treat cancer. C. Mutation in p53 is a type of passenger mutation. D. One driver mutation is more than sufficient for the production of a cancer phenotype.arrow_forwardP53 is a tumor suppressors protein. The protein is present in the cell at all times but is activated by protein kinases that are, in turned activated by DNA damage. A mutation of the P 53 gene in cell results in a form of P53 that is permanently active. What would happen to the mutant version of the P53 gene? Group of answer choices A. it would spread to neighboring cells but not very far B. it would be found in tumor cells only C. it would take over the world and make us all do its bidding D. it would only be found in the original cell in which the mutation occurred E. it would spread to all cells in the bodyarrow_forward
- Which of the following statements are true about the rate of mutation in tumor cells (select all that apply)? A. Mutation rate of tumor cells is reduced compared to normal cells of the same tissue type B. Mutation rate of tumor cells is unchanged compared to normal cells of the same tissue type C. Mutation rate in tumor cells is higher compared to normal cells of the same tissue type D. Affected by genome instability within the tumor cellsarrow_forwardWith regard to cancer cells, which of the following are true? A. Cancer cells are clonal, meaning that they are derived from many different cells that all underwent the same clonal mutation. Cells usually accumulate many mutations over time, and this results in cancerous growth. B. Almost all cancers are caused by oncogenic viruses. no Benign tumors are dangerous because they can easily invade surrounding tissue and spread to other locations in the body. DE. Cancer cells are unable to control their division.arrow_forwardMutations in the ras gene family induce normal cells to proceed into the replication cycle. This converts the ras gene from a ________ gene to a ________ gene. a. proto-oncogene; oncogene b. oncogene; proto-oncogene c. mutant; oncogene d. tumor suppressor; proto-oncogenearrow_forward
- Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.arrow_forwardWhich of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply: a. Increasing tumor's access to oxygen and nutrients b. Increasing tumor's ability for growth, invasion, and metastasis c. Increasing expression of proto-oncogenes for cancer cells d. Increasing expression of tumor-suppressor genes for cancer cellsarrow_forwardTumor Suppressor Genes are often called as gatekeepers because: a. They signify their involvement in governing the dynamics of cell proliferation b. They allow tumors to proliferate at an uncontrolled rate c. To allow a transport channel of suppressors d. They are not referred to as ?gatekeepers?arrow_forward
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