Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 18, Problem 23RQ
Summary Introduction
To review:
The reasons for most mutations being detrimental, and rarely being beneficial.
Introduction:
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Question 47
(a) Use the following figure to determine the changes to the amino acids that
correspond to the normal and mutated DNA sequences. Normal DNA sequence: 3
CAT TCA AAC ATT 5 Mutated DNA sequence: 3 CAT AGT GAG GTC 5 (Hint: Write
the mRNA first, then identify the amino acids.) (b) What type of mutation is shown?
First base of codon
U
C
A
G
U
UUU
UUC
UUA
UUG
CUU
CUC
CUA
CUG
AUU
AUC
AUA
AUG
GUU
GUC
GUA
GUG
UCU
UCC
UCA
UCG
CCU
CCC
CCA
CCG
ACU
ACC
ACA
Met ACG
GCU
GCC
GCA
GCG
Phe
-Leu
Leu
lle
Second base of codon
A
C
Val
-Ser
Pro
Thr
Ala
UAUTYT
туг
UAC
UAA
UAG
CAU
CAC
CAA
CAG.
His
Gin
AAU
AAC Asn
AAA
GAUT
GAC
GAA
GAG
Asp
G
AAGLYS AGG.
GGU
GGC
GGA
GGG
Glu
UGU
UGC
UGA
UGG
CGU
CGC
CGA
CGG
Bys
A
Trp G
U
C
-Arg
AGU
AGC
AGA
аса за
Ser
Arg
U
C
Gly
AG
A
U
C
A
G
U
C
A
G
Third base of codon
Question 33
Explain why harmful mutations tend to disappear, while
beneficial mutations become widespread.
Question 2:
Part a: Complete the table describing different components of intron removal from mRNA. Nu:, X and Y refer to B-type chemistry shown on the previous page. (YELLOW table shown)
Part b: Complete the table describing different components of group I self-splicing intron removal from 26S rRNA in Tetrahymena. (BLUE table shown)
Part c: Draw the intron with an all atom structure for Branchpoint A after intron removal from mRNA
Part d: Draw the Group I self-splicing intron with an all atom structure for the Guanosine cofactor after intron removal from 26S rRNA in Tetrahymena.
Chapter 18 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 18 - Prob. 1QCh. 18 - Prob. 2QCh. 18 - Prob. 3QCh. 18 - Prob. 4QCh. 18 - Prob. 5QCh. 18 - Prob. 1RQCh. 18 - Prob. 2RQCh. 18 - Prob. 3RQCh. 18 - Prob. 4RQCh. 18 - Prob. 5RQ
Ch. 18 - Prob. 6RQCh. 18 - Prob. 7RQCh. 18 - Prob. 8RQCh. 18 - Prob. 9RQCh. 18 - Prob. 10RQCh. 18 - Prob. 11RQCh. 18 - Prob. 12RQCh. 18 - Prob. 13RQCh. 18 - Prob. 14RQCh. 18 - Prob. 15RQCh. 18 - Prob. 16RQCh. 18 - Prob. 17RQCh. 18 - Prob. 18RQCh. 18 - Prob. 19RQCh. 18 - Prob. 20RQCh. 18 - Prob. 21RQCh. 18 - Prob. 22RQCh. 18 - Prob. 23RQCh. 18 - Prob. 24RQCh. 18 - Prob. 25RQCh. 18 - Prob. 26RQCh. 18 - Prob. 27RQCh. 18 - Prob. 28RQCh. 18 - Prob. 29RQCh. 18 - Prob. 30RQCh. 18 - Prob. 31RQCh. 18 - Prob. 32RQCh. 18 - Prob. 33RQCh. 18 - Prob. 34RQCh. 18 - Prob. 35RQCh. 18 - Prob. 36RQCh. 18 - Prob. 37RQCh. 18 - Prob. 38RQCh. 18 - Prob. 39RQCh. 18 - Prob. 40RQCh. 18 - Prob. 41RQCh. 18 - Prob. 42RQCh. 18 - Prob. 43RQCh. 18 - Prob. 44RQCh. 18 - Prob. 45RQCh. 18 - Prob. 46RQCh. 18 - Prob. 47FBCh. 18 - Prob. 48FBCh. 18 - Prob. 49FBCh. 18 - Prob. 50FBCh. 18 - Prob. 51FBCh. 18 - Prob. 52FBCh. 18 - Prob. 53FBCh. 18 - Prob. 54FBCh. 18 - Prob. 55FBCh. 18 - Prob. 56FBCh. 18 - Prob. 57SACh. 18 - Prob. 58SACh. 18 - Prob. 59SACh. 18 - Prob. 60SACh. 18 - Prob. 61SACh. 18 - Prob. 62TQCh. 18 - Prob. 63TQCh. 18 - Prob. 64TQCh. 18 - Prob. 65TQCh. 18 - Prob. 66TQCh. 18 - Prob. 67TQCh. 18 - Prob. 68TQCh. 18 - Prob. 69TQCh. 18 - Prob. 70TQCh. 18 - Prob. 71TQCh. 18 - Prob. 72TQCh. 18 - Prob. 73TQCh. 18 - Prob. 74TQCh. 18 - Prob. 75TQ
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