SEELEY'S ANATOMY+PHYSIOLOGY
SEELEY'S ANATOMY+PHYSIOLOGY
12th Edition
ISBN: 9781260172195
Author: VanPutte
Publisher: RENT MCG
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Chapter 17, Problem 7CT

Thyroid hormones are important in regulating the body's basal metabolic rate. Thyroid hormones are lipid-soluble and have a long half-life. What are the advantages and disadvantages of a long half-life for thyroid hormones, compared with a short half-life?

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Take thyroid hormones as an example of hormones and their properties. Thyroid hormone is highly bound to proteins in the blood. What is the benefit of such protein binding? What effect does protein binding have on the activity of the hormone? Name a gland other than the thyroid gland that is involved in regulating thyroid hormone production?
You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs). Peroxidine: A drug that inhibits thyroid peroxidase from functioning Cimigine: A drug that inhibits potassium/iodine cotransporter Iodimine: A drug that inhibits iodinase from functioning Aldosine: A drug that inhibits production of angiotensinogen from the liver Aldoramine: A drug that inhibits sodium/iodine cotransporter Thyromine: A drug that stimulates thyroglobulin production Identify the drug(s) that would be successful in treating hyperthyroidism and hypothyroidism, and explain why and how they…
You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs). Please identify the drug(s) that would be successful in treating hypothyroidism, and explain why and how they would be successful. Aldosine: A drug that inhibits production of angiotensinogen from the liver Aldoramine: A drug that inhibits sodium/iodine cotransporter Thyromine: A drug that stimulates thyroglobulin production Peroxidine: A drug that inhibits thyroid peroxidase from functioning Cimigine: A drug that inhibits potassium/iodine cotransporter Iodimine: A drug that inhibits iodinase from…

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SEELEY'S ANATOMY+PHYSIOLOGY

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