The level of activity of the enzyme coded by ‘A’ allele compared to the enzyme coded by ‘G’ allele. Given: In the given experiment, the rate of metabolism and drug concentration after 12 hours of administration is correlated with different genotypes of single nucleotide polymorphisms (SNP) 5689. The results are shown as given in the diagram below: Introduction: The metabolism of drug is effective in people with genotype GG where drug concentration in the blood is around 70. The drug concentration for the genotype AG is around 100 and it is around 130 for AA genotype. It is assumed that the SNP 5689 is present in a gene, which encodes an enzyme. This enzyme breaks down the drug.

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Chapter 17, Problem 3Q

Summary Introduction

To review:

The level of activity of the enzyme coded by ‘A’ allele compared to the enzyme coded by ‘G’ allele.

Given:

In the given experiment, the rate of metabolism and drug concentration after 12 hours of administration is correlated with different genotypes of single nucleotide polymorphisms (SNP) 5689. The results are shown as given in the diagram below:

Introduction:

The metabolism of drug is effective in people with genotype GG where drug concentration in the blood is around 70. The drug concentration for the genotype AG is around 100 and it is around 130 for AA genotype. It is assumed that the SNP 5689 is present in a gene, which encodes an enzyme. This enzyme breaks down the drug.

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