Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 17.4, Problem 2R
Summary Introduction
To review:
The use of haplotype mapping to find the effectiveness of a drug in a patient.
Introduction:
The study of the effectiveness of the drug based on information about individual genome is called pharmacogenomics. Haplotype mapping is the identification of single
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identify the alleles of the genetic marker only for diseased individuals in the pedigree
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calculate a Lod score
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Life: The Science of Biology
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- If a pregnant woman had a karyotype prepared for her baby before birth, would it be more useful in predicting the risk of Down Syndrome or Tay Sachs disease? Explain your answer completely and in detail.arrow_forwardWhat is a molecular marker? Elaborate physical chromosome mapping with the help of molecular markersarrow_forwardWhat is the relevance of a Chi-square test in Geneticsarrow_forward
- Imagine that you are a new breeder for caique parrots. You can sell normal green feather birds for $500 a bird. The mutation for blue feathers is rare and birds with this color can sell for $3000 a bird. Your goal is to produce as many blue feather offspring as you can, but you don't have the budget to buy blue feather birds as parents. Question: What genotype should you purchase for both parent blrds to get the best chance of getting blue feather offspring? Create and use your Punnett square results as evidence to support your answer. You will need to make multiple Punnett Squares to see which parent genotypes makes the most blue feathered offspring. Keep in mind that Green fealhers (G) is dominant over blue feathers (g), so birds with blue feathers have the genotype gg. Some Punnett squares are provided for you to determine the possible crosses, but remember yoU cannot afford a blue feathered bird, so neither of your parent birds can have the genotype gg. Complete a Punnett Square…arrow_forwardWild-type strains of the haploid fungus Neurospora canmake their own tryptophan. An abnormal allele td renders the fungus incapable of making its own tryptophan.An individual of genotype td grows only when its medium supplies tryptophan. The allele su assorts independently of td; its only known effect is to suppress the tdphenotype. Therefore, strains carrying both td and su donot require tryptophan for growth.a. If a td ; su strain is crossed with a genotypically wildtype strain, what genotypes are expected in the progenyand in what proportions?b. What will be the ratio of tryptophan-dependent totryptophan-independent progeny in the cross of part a?arrow_forwardA representation of the distance between genes or genetic markers is called a?arrow_forward
- describes an example of a maternal effect gene. Explainhow Sturtevant deduced a maternal effect gene based on the F2 andF3 generations.arrow_forwardHow does the picture in a illustrate transmission genetics?arrow_forwardBelow is a DNA profile of an individual. Use the diagram below and your knowledge from lecture to answer the questions below. 1. The single peak at D16S539 means that the individual has only one copy of D16S539. 2. The individual is homozygous for both the D5S818 and D7S820 loci. 3. The individual is heterozygous for the D16S539 locus. 4. The numbered boxes at the bottom represent the number of repeats. D5S818 D13S317 D7S820 D16S539 CSFIPO Number of Base Pairs 100 200 300 11 12 9 13 13|1ג| 11 10 11 A. 1, 2 and 3 B. 1 and 3 C. 2 and 4 D. 4 only E. All of 1, 2, 3 and 4 are correct. Relative Fluorescencearrow_forward
- Why is karyotyping significant in understanding chromosomal abnormalities? Short essay only thanks please the main answerarrow_forwardRefer to the sequence characteristics of the alleles for Gene A (A1 = Allele 1 and A2 = Allele 2) below: Question: What DNA marker system can be developed for Gene A as characterized above, for example to study A-allele diversity? Briefly describe your proposed DNA marker i.e. concept overview, type/frequency/site of DNA mutation, method of resolution, genetic inheritance, etc.arrow_forwardWhat advantages do anonymous DNA markers afford for genetic mapping as opposed to traditional allelic markers associated with visible phenotypes? What are the disadvantages of anonymous DNA markers for mapping?arrow_forward
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Genome Annotation, Sequence Conventions and Reading Frames; Author: Loren Launen;https://www.youtube.com/watch?v=MWvYgGyqVys;License: Standard Youtube License