Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 17, Problem 2Q
Summary Introduction
To review:
The dose levels for the individuals with AA genotypes compared to the individuals with GG genotype at single
Given:
In the given graph, the rate of
Introduction:
The metabolism of drug is effective in people with genotype GG where drug concentration in blood is around 70. The drug concentration for the genotype AA is around 130. The concentration of drug in the blood for the AA and GG genotypes differs because of the difference in the rate of metabolism.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Explain this statement "Major considerations in dosage form design with example" ? Please briefly explain at your own easy words.
stion 6 of 18
Suppose that a geneticist discovers a new mutation in Drosophila melanogaster that causes the flies to shake and quiver.
She calls this mutation quiver, qu, and determines that it is due to an autosomal recessive gene. She wants to determine
whether the gene encoding quiver is linked to the recessive gene for vestigial wings, vg. She crosses a fly homozygous for
quiver and vestigial traits with a fly homozygous for the wild-type traits, and then uses the resulting F, females in a
testcross. She obtains the flies from this testcross.
Phenotype Number of flies
vg* qu+
230
vg qu
224
vg qut
vg* qu
97
99
Test the hypothesis that the genes quiver and vestigial assort independently by calculating the chi-squared, X², for this
hypothesis. Provide the X2 to one decimal place.
X2 =
Does the X value support the hypothesis that the quiver and vestigial genes assort independently? Why or why not?
the partial table of critical values for X2 calculations to test this hypothesis.
Explain the multiple testing problem of GWAS - why do we need such a small p-value to achieve significance?
Chapter 17 Solutions
Life: The Science of Biology
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Is the heritability of COVID-19 susceptibility is close to 1? Based on your knowledge, what is the potential role of the environment in determining susceptibility to COVID-19?arrow_forwardA SNP that can exist as a C or G is associated with a human disease. The genotypic odds ratio of the homozygote CC relative to the homozygote GG is 2.2, which indicates that a)both CC and GG individuals are equally likely to get the disease because 2.2 is not a significant value. b)heterozygotes are 2.2 times as likely to get the disease as GG homozygotes. c) CC homozygotes are 2.2 times as likely to get the disease as GG homozygotes. d) CC homozygotes are 2.2 times less likely to get the disease as GG homozygotes.arrow_forwardStarting with an AA, 2n = 14 genome of Triticum urartu (wild einkorn wheat) and a BB, 2n = 14 genome of Triticum speltoides (wild grass), show a pathway to obtain AABBDD, 2n = 42 Triticum spelta (spelt wheat) that is commonly used in cereals, pasta, and bread.arrow_forward
- I have seen that this was answered as C, Why is the answer C, how is that not evidence of it being genetic? Shouldnt it be none of the above? Question: Of the following, which supports the idea that alcoholism has no genetic or a low genetic component? a) Some strains of mice select alcohol over water 75% of the time, whereas others shun alcohol. b) The concordance value is 55% for MZ twins and 28% for DZ twins. c) Biological sons of alcoholic men who have been adopted have a rate of alcoholism more like that of their adoptive fathers. d) There is a 20% to 25% risk of alcoholism in the sons of alcoholic men. e) None of these.arrow_forwardWhich parameters are important to include when designing a GWAS (genome-wide association study) to identify genes involved in Polycystic Kidney disease in individuals of Korean ancestry? Select all that apply. Group of answer choices a. Compare Korean individuals with the disease to unaffected Korean individuals b. Pursue SNPs only in exonic loci for further study c. Pursue SNPS only in genes related to kidney development for further study d. Set strong statistical thresholds to identify SNPs related to the disease state over the general variation observed in populations e. Compare Korean individuals with the disease to every available genome for a stronger statistical power.arrow_forwardPlease answer all parts along with the reason. I'll definitely give a like. Thank you in advance! 1A) From the cross Ab/aB x ab/ab, what is the recombination frequency if the progeny numbers are 17 AB/ab, 72 Ab/ab, 68 aB/ab, and 21 ab/ab? 1B)In human gene mapping, a LOD score is calculated to see if a gene causing a rare disease is linked to a known SNP. The LOD score is -4. This means that 1C) A three-point testcross is used to determine the order of three linked genes. The following crossover progeny result: single crossovers, double crossovers, and no crossovers. To determine the order, the no-crossover progeny must be compared to what other class of progeny?arrow_forward
- Use the scoring system described to calculate the alignment score for IPNI AAIG DV VAGP VKGIYA VG DV C-GK Scoring system: • Each identity results in +10 points. • Each gap has a penalty of -25 points. score = What is the percent identity (also called percent identity match)? percent identity: %arrow_forward(a) Explain sensitivity and selectivity in terms of true and false positives. (b) What is the advantage of a Needleman-Wunsch alignment compared to a seeded alignment? (c) What does the expectation parameter mean in local alignment? What will happen if the expectation value is increased from its default value of 10 to a 100?arrow_forwardA. Clearly there is significant genetic variation associated with susceptibility to COVID-19. Does that mean that the heritability of COVID-19 susceptibility is close to 1? Based on your knowledge, what is the potential role of the environment in determining susceptibility to COVID-19? B. What is the utility of understanding the genetic basis of susceptibility to COVID-19 for medicine and public health? Can you think of potential applications of this knowledge?arrow_forward
- The following data for the genotypes at the alcohol dehydrogenase locus were observed from a sample of Drosophila melanogaster. Sample size 1000 FF 550 FF=0.55; FS=0.34; SS=0.11 O F-0.72; S=0.28 FF=0.078; FS=0.40; SS=0.52 FS What are the Hardy-Weinberg equilibrium genotype frequencies for each genotype based upon this sample? OFF=0.52; FS=0.40; SS=0.078 340 SS 110arrow_forwardWhat is the expected genotype frequency of the heterozygous genotype under the Hardy-Weinberg equation P = 0.7?arrow_forward(b). The S-s antigen system in human is controlled by two codominant alleles, S and s. In a group of 3146 individuals, the following genotypic frequencies were found: 188 SS, 717 Ss, and 2241 ss. Calculate the frequency of s. O q = 0.8263 O q = 0.9402 O q = 0.4701 O q = 0.1438arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
An Introduction to the Human Genome | HMX Genetics; Author: Harvard University;https://www.youtube.com/watch?v=jEJp7B6u_dY;License: Standard Youtube License