Biology (MindTap Course List)
11th Edition
ISBN: 9781337392938
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Chapter 17.3, Problem 8LO
Summary Introduction
To explain: The relationship between cancer and change in the gene expression that affects cell development processes.
Introduction: Cancer refers to the abnormal growth of cells in the body, which causes an abnormal increase in the number of cells. This prevents the differentiation and growth of the organs. The genes regulating the activity of cancer cells are called oncogenes.
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Explain in detail two different genetic mutations that can promote the development of cancer. Include the name (or type) of gene mutated and whether the expression of the gene is upregulated or downregulated. Provide a description of the role the gene plays in regulating the cell cycle and how the cell is affected when the gene no longer produces a functional protein
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Explain the molecular mechanisms of cancers caused by a P53 gene mutation.
Chapter 17 Solutions
Biology (MindTap Course List)
Ch. 17.1 - Prob. 1LOCh. 17.1 - Describe the classic experiments of Steward,...Ch. 17.1 - Define stem cells, distinguish between embryonic...Ch. 17.1 - What lines of evidence support the principle of...Ch. 17.1 - Prob. 2CCh. 17.1 - What does the ability to produce iPSCs tell...Ch. 17.2 - Prob. 4LOCh. 17.2 - Prob. 5LOCh. 17.2 - Prob. 6LOCh. 17.2 - Prob. 7LO
Ch. 17.2 - Prob. 1CCh. 17.2 - Prob. 2CCh. 17.2 - Prob. 3CCh. 17.2 - Prob. 4CCh. 17.3 - Prob. 8LOCh. 17.3 - Prob. 1CCh. 17.3 - Prob. 2CCh. 17 - Prob. 1TYUCh. 17 - Prob. 2TYUCh. 17 - The anteriorposterior axis of a Drosophila embryo...Ch. 17 - Prob. 4TYUCh. 17 - Homeobox genes (a) are found in fruit flies but no...Ch. 17 - Prob. 6TYUCh. 17 - Prob. 7TYUCh. 17 - Which of the following statements about cancer is...Ch. 17 - Proto-oncogenes code for (a) morphogens (b)...Ch. 17 - Prob. 10TYUCh. 17 - Prob. 11TYUCh. 17 - Prob. 12TYUCh. 17 - CONNECT Why is an understanding of gene regulation...Ch. 17 - What is the reason that scientists study...Ch. 17 - Prob. 15TYUCh. 17 - Prob. 16TYUCh. 17 - EVOLUTION LINK What is the common ground between...Ch. 17 - INTERPRET DATA Flower parts are arranged in four...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- examine the process of gene expression. Include the following: Explain the regulation of gene expression in eukaryotic cells. Discuss mechanisms by which gene expression may be altered. How do these alterations induce cancer-causing mutations in cell DNA? Explain how cancer is formed. Describe genetic changes found in cancer cells and how these changes lead to alterations in cell behavior. Determine whether proteome data can be utilized in genetic disorder diagnosis. Relate the Human Genome Project data to the analysis of cancer genes. Relates the Human Genome Project's utility in pharmacogenomics and personalized medicine to diagnose and treat cancerarrow_forwardExplain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause dominantly inherited predispositions to cancer.arrow_forwardExplain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and how might gene therapy or other drug interventions inhibit the growth of a tumor?arrow_forward
- Discuss why certain cell types are less likely and others are more likely to develop cancer than others.arrow_forwardDescribe the differences between point mutations, chromosomal translocations, and gene amplification in the process of cancer.arrow_forwardDiscuss how oncogenes and tumor suppressor genes are related to genes involved in the control of normal growth and development.arrow_forward
- Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forwardCompare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes. Describe the types of mutations that convert proto-oncogenes into oncogenes. Summarize some functions of common oncogenes in cell survival and uncontrolled growth. Contrast tumor suppressors to oncogenes. Describe the types of mutations in tumor suppressors that are found in common cancers. Summarize the functions of common tumor suppressors in cell survival and cell growth.arrow_forwardWhich genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is associated with the early onset of cancers and the development of multiple malignant lesions of diverse tissue origins?arrow_forward
- Describe DNA Mutations: Definition: Define a mutation. Are they good or bad? What types of mutations can occur in the DNA? What can cause a mutation? Can mutation be “fixed”? What are the requirements for normal cell division? What are the requirements for cancer cells to divide and grow? Define the difference between a benign tumor, a malignant tumor, and metastatic cancer.arrow_forwarddescribe how mutations in proto-oncogenes and tumor suppressor genes cause most types of cancerarrow_forwardExplain Mutations in tumor-suppressor genes are recessive at the cellular level but dominant at the organismal level.arrow_forward
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