Concept explainers
To determine: Whether it is advantageous if the regulatory gene that codes for the tryptophan repressor is tightly linked to the trp operon.
Introduction: Gene regulation consists of many mechanisms that the cell uses to decrease or increase the production of certain gene products. The gene regulation in the bacteria mainly takes place in the level of transcription. In the eukaryotes, the gene regulation takes place in the level of transcription, post transcription, translation, and post translation.
To explain: The reason why there is no advantage if the regulatory gene that codes for the tryptophan repressor is tightly linked to the trp operon.
Introduction: Gene regulation consists of many mechanisms that the cell uses to decrease or increase the production of certain gene products. The gene regulation in the bacteria mainly takes place in the level of transcription. In the eukaryotes, the gene regulation takes place in the level of transcription, post transcription, translation, and post translation.
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Biology (MindTap Course List)
- INTERPRET DATA Develop a simple hypothesis that would explain the behavior of each of the following types of mutants in E. coli. Mutant a: The map position of this mutation is in the trp operon. The mutant cells are constitutive; that is, they produce all the enzymes coded for by the trp operon, even if large amounts of tryptophan are present in the growth medium. Mutant b: The map position of this mutation is in the trp operon. The mutant cells do not produce any enzymes coded for by the trp operon under any conditions. Mutant c: The map position of this mutation is some distance from the trp operon. The mutant cells are constitutive; that is, they produce all the enzymes coded for by the trp operon, even if the growth medium contains large amounts of tryptophan.arrow_forwardWhat would happen to the regulation of the tryptophan operon in bacterial cells that express a mutant form of the tryptophan repressor that (1) cannot bind to DNA, (2) cannot bind tryptophan, or (3) binds to DNA even in the absence of tryptophan?arrow_forwardUnder low tryptophanyl-tRNA (tRNAtrp), we expect the trp operon to be expressed because: Question 13 options: Sections 1 and 2 of the leader form a hairpin that acts as a transcriptional terminator. Sections 2 and 3 of the leader form a hairpin that prevents the formation of a transcriptional terminator. Sections 1 and 2 of the leader form a hairpin that prevents the formation of a transcriptional terminator. Sections 2 and 3 of the leader form a hairpin that acts as a transcriptional terminator. Sections 3 and 4 of the leader form a hairpin that acts as a transcriptional terminator.arrow_forward
- Consider the trp operon found in E. coli. You have discovered a mutant strain of E.coli that contains a mutation in its trpR gene. This mutation prevents the trpR protein from binding to its small effector molecule. What would happen if both the wild type and mutant bacteria were put in an environment that contained lots of tryptophan? The normal (wild type) bacteria would have (i)________expression of the trp operon while the mutant bacteria would have (ii) _________ expression of the trp operon. A) (i) high (ii) high B) (i) low (ii) low C) (i) high (ii) low D) (i) low (ii) higharrow_forwardSuppose you are studying the regulation of a gene involved in the metabolism of two nutrients, Llamasin and Alpacalon, in bacteria. You are trying to determine if these nutrients act as inducers in their operons. The following data were collected from your experiments. Which of these operons is most similar to the lac operon? Explain. Nutrient Levels of nutrient in growth medium Level of transcription of genes in operon Llamasin low high high low Alpacalon low low high high Highlight one in green: Llamasin Alpacalon Explanation:arrow_forwardDraw a schematic diagram showing the components involved in the regulation of the tryptophan operon.arrow_forward
- . In the tryptophan operon of E. coli, what happens when tryptophan levels get too high? tryptophan is removed from its co-repressor, causing it to detach from the operator tryptophan is removed from its co-repressor, causing it to attach to the operator tryptophan is bound to its co-repressor, causing it to detach from the operator tryptophan is bound to its co-repressor, causing it to attach to the operator all of the above occur at equal rates when tryptophan levels get too higharrow_forwardWhich of the following statements about the trp operon is false? If a mutation in region 2 prevents the formation of the 2 + 3 loop in the 5’UTR transcription levels will increase. The trp operon is an example of negative repressible operon. Formation of the anti-terminator in the 5’UTR of the trp operon occurs when trp levels are low. In the presence of high trp-tRNA, the genes of the trp operon are not expressed. The role of trp is to bind to the repressor protein and activate it.arrow_forwardIn the lac operon (below), how will expression of the genes lacZ and lacy be effect by a mutation in the repressor protein (encoded by lach) that prevents it from binding the operator sequence (lacO) in the absence of lactose? Explain the answerarrow_forward
- Tryptophan (Trp) attenuation is an extra mechanism of regulation of trp operon when trp level is too high. Attenuation causes premature transcription termination. b) Predict what will happen if trp repressor lose its allosteric effect.arrow_forwardSuppose that E. coli sustains a mutation in its gene for the lac operon repressor such that the repressor is ineffective. What effect would this have on the bacterium’s ability to catabolize lactose? Would the mutant strain have an advantage over wild-type cells? Explain your answer.arrow_forwardIs the regulator protein that binds to the operator of this operon a repressor (negative control) or an activator (positive control)? Explain your reasoning.arrow_forward
- Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning