Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 13, Problem 10P
The term heterochromatin refers to heavily condensed regions of chromosomes that are largely devoid of genes. Since few genes exist in those regions, they almost never decondense for transcription. At what point during the cell cycle would you expect to observe the decondensation of heterochromatic regions? Why?
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Students have asked these similar questions
The interphase is the part of the eukaryotic cell cycle that is most transcriptionally active. Gene regulation during this phase involves changes in the chromatin.
a) What is chromatin?
b) How can the chromatin structure change?
Consider the figure beow, which depicts chromatin within the neucleus of a eukaryotic cell.
nucleus
O The letter A indicates regions of a single chromosome which are not expressed, and the letter B indicates
regions of a single chromosome which are expressed.
O Both answer choice A and answer choice B are correct.
The letter A indicates regions of a single chromosome which are condensed and attached to the nuclear
lamina, and the letter B indicates regions of a single chromosome which are partially decondensed.
O Answer choices A, B and C are all correct.
O The letter A represents repressed TADS, and the letter B represents active TADS.
What is the relation between the concepts of chromatin andchromosome? Are euchromatin and heterochromatin part of chromosomes?
Chapter 13 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 13 - 13.1 Devoting a few sentences to each, describes...Ch. 13 - 13.2 Describe and give an example (real or...Ch. 13 - What is meant by the term chromatin remodeling?...Ch. 13 - 13.4 What general role does acetylation of histone...Ch. 13 - 13.5 Describe the roles of writers, readers, and...Ch. 13 - Outline the roles of RNA in eukaryotic gene...Ch. 13 - 13.7 What are the roles of the Polycomb and...Ch. 13 - Most biologists argue that the regulation of gene...Ch. 13 - Compare and contrast the transcriptional...Ch. 13 - The term heterochromatin refers to heavily...
Ch. 13 - 13.11 Compare and contrast promoters and enhancers...Ch. 13 - 13.12 What are the different chromatin...Ch. 13 - 13.13 Define epigenetics, and provide examples...Ch. 13 - What is one proposed role for lncRNAs?Ch. 13 - 13.15 What are the sources of dsRNA? Diagram the...Ch. 13 - How does dsRNA lead to posttranscriptional gene...Ch. 13 - 13.17 A hereditary disease is inherited as an...Ch. 13 - Prob. 18PCh. 13 - Prob. 19PCh. 13 - 13.20 A muscle enzyme called ME is produced by...Ch. 13 - Using the components in the accompanying diagram,...Ch. 13 - 13.22 The majority of this chapter focused on gene...
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- Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forwardOne change observed at the centrosomes early in mitosis is an increase in the number of γ-TURCcomplexes (which contain γ-tubulin.).How does the presence of γ-tubulin affect the balance between microtubule assembly & disassembly? Why might having more of it present in the centrosomal region be beneficial in the spindle assembly process?arrow_forwardWhat is chromatin condensation?arrow_forward
- Duplication of chromatin material takes place in which phase?arrow_forwardFigure 3.7 shows a syncytial Drosophila embryo, a single large cell that can contain hundreds or even thousands of nuclei. Each round of nuclear division can occur rapidly, sometimes as quickly as 10 minutes. These rapid divisions do not require all the stages seen in a normal cell cycle. Which stages (G1, S, G, mitosis, cytokinesis) are dispensable and which are not? Explain.arrow_forwardThe mitotic spindle is often described as a microtubule based cellular machine. The microtubules that constitute the mitotic spindle can be classified into three distinct types. What are the three types of spindle microtubules, and what is the function of each?arrow_forward
- In which phases of the cell cycle would you expect double-strand break repair and nonhomologous end joining to occur and why?arrow_forwardWhich of the following represents the order of increasingly higher levels of organization of chromatin? Select one: O a. looped domain, nucleosome, 30-nm chromatin fiber O b. 30-nm chromatin fiber, nucleosome, looped domain C. nucleosome, looped domain, 30-nm chromatin fiber O d. looped domain, 30-nm chromatin fiber, nucleosome nucleosome, 30-nm chromatin fiber, looped domain е.arrow_forwardDraw and label G1 and G2 stages of interphase and each stage of mitosis (in order) for a cell that has two large and two small chromosomes, 2n=4. For unreplicated chromosome draw a line ( / ) and for replicated chromosome draw an X. Since we are focusing on the DNA, you can skip drawing the nuclear membrane or spindle fibers. For simplicity, do not indicate that the chromosomes are decondensed chromatin during interphase. Mark and label a place on one of the large chromosomes with the dominant allele of the “A” gene and put the recessive allele “a” on the other homolog. Mark and label a place on one of the small chromosomes with allele “B” and put the recessive allele “b” on the other homolog.arrow_forward
- A mitotic spindle is a structure formed in [Select] [Select] types of microtubules. [Select] while [Select] located at opposite ends of the cell. Within each of these are 3 cells that consists of a mitosis. Finally, without [Select] connection between the two spindle poles. microtubules help position each spindle, microtubules help to pull sister chromatids apart during microtubules, there would be noarrow_forwardDefine the following terms: a. chromosome b. chromatinarrow_forwardHow can the chromatin structure change?arrow_forward
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