Chapter 12.2, Problem 4COQ

Summary Introduction

To draw:

A molecule of DNA undergoing rolling-circle replication, labeling with

(a) Origin of replication,

(b)Polarity (5 and 3 ends) of all template strands and newly synthesized strands,

(c)Leading and lagging strands,

(d) Okazaki fragments, and

(e)Location of primers.

Introduction:

In DNA replication, a double stranded DNA moleculeis producedamong two complementary strands of nucleotides.Rolling circle method of DNA replication, demonstrates a unidirectional replication of nucleic acid which synthesizes multiple copies of DNA or RNA rapidly. For example,plasmids, bacteriophages and the genome of viroids.