Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 12.10, Problem 1GR
Summary Introduction
To determine: If the cancer stem cell hypothesis undercut the idea that cancers have a clonal origin, or can these two ideas be reconciled.
Introduction: Stem cells are the undifferentiated mass of cells that continue to divide until specific signals lead to their differentiation. The differentiation results in the conversion of stem cells into a specific type of cells in a cell lineage. Cancer cells also show continuous division but these cells are differentiated cells and are harmful to the body.
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Chapter 12 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 12.10 - If improved diagnostic tests are developed from...Ch. 12.10 - If you had cancer, would you donate tissue samples...Ch. 12.10 - Prob. 1GRCh. 12.10 - Another model, the random model, proposes that any...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Theodor Boveri predicted that malignancies would...Ch. 12 - Distinguish between a familial and a sporadic...Ch. 12 - Benign tumors: a. are noncancerous growths that do...
Ch. 12 - Prob. 4QPCh. 12 - Prob. 5QPCh. 12 - Prob. 6QPCh. 12 - Prob. 7QPCh. 12 - Prob. 8QPCh. 12 - What is the difference between a proto-oncogene...Ch. 12 - Distinguish between dominant inheritance and...Ch. 12 - Describe the likelihood of developing bilateral...Ch. 12 - Prob. 12QPCh. 12 - The search for the BRCA1 breast cancer gene...Ch. 12 - What are the roles of cellular proto-oncogenes,...Ch. 12 - Which of the following mutations will result in...Ch. 12 - Prob. 16QPCh. 12 - The following family has a history of inherited...Ch. 12 - You are in charge of a new gene therapy clinic....Ch. 12 - Prob. 19QPCh. 12 - Can you postulate a reason or reasons why children...Ch. 12 - Prob. 21QPCh. 12 - In Section 12-1, Julie is concerned that she may...Ch. 12 - Prob. 23QPCh. 12 - What are some factors that epidemiologists have...Ch. 12 - Smoking cigarettes has been shown to be associated...Ch. 12 - Prob. 26QPCh. 12 - Studies have shown that there are significant...
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- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardCan we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how can this be?arrow_forwardCan we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?arrow_forward
- What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.arrow_forwardWhat is the difference between a proto-oncogene and a tumor-suppressor gene?arrow_forwardCan restoring tumor suppressor function, such as mutant p53 or pRb, be used to cure cancer? If that's the case, how is it possible?arrow_forward
- If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking cause cancer?arrow_forwardWhy is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings.arrow_forwardWhat is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to cancer?arrow_forward
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