Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how can this be?
Q: How can a defect in p53 gene contribute to cancer development?
A: Cancer is an abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some…
Q: How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the…
A: Epigenetics is the study of various alterations in an organism occurred because of certain gene…
Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…
A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…
Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…
A: False statement about tumor suppressor genes.
Q: Why do most cancer treatments at present target microtubule formation of the cell? What are the most…
A: Cancer is a systemic disease which occurs within the body cells and tissues and eventually spreads…
Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
A: Genetic transformation happens when the genetic composition of an organism is transformed by the…
Q: Distinguish between proto-oncogenes and tumor suppressor genes?
A: The proto-oncogenes are those genes, which promote the cell cycle and inhibit apoptosis of the…
Q: Which of the following is NOT an example of fail-safe mechanisms that prevent the irregular cell…
A: Cancer is the uncontrolled cell division where he ell continuously divides. Cancer cells thus become…
Q: If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking…
A: Tumor is a mass of tissues. It may be benign or malignant. The cellular growth that occurs when the…
Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…
A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…
Q: Explain the role of epigenetic alterations in cancer ?
A: Genes are the hereditary unit in an organism and are passed on from the parental generation to the…
Q: How interfered regulatory machinery results in production of tumor?
A: Eukaryotes have well-organized nucleus. prokaryotes are devoid of nuclear arrangements. genome…
Q: Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop…
A: Cancer refers to the uncontrolled cell division caused by the mutations in the genes which control…
Q: One important biological effect of a large dose of ionizing radiation is to halt cell division. What…
A: Cell division is the cycle by which a parent cell separates into at least two girl cells. Cell…
Q: Which of the following is not a tumor suppressor gene? a.RET b.RB c.BRCA1 d.BRCA2
A: A normal cell undergoes regulated division, differentiation, and apoptosis (programmed cell death).…
Q: Describe how Ras and p53 can alter the simplified genetic pathway controlling cell division shown…
A: There are two general types of genes that play a fundamental role in cancer induction:…
Q: illustrate some of the molecular mechanisms leading from loss-of-function mutations in…
A: Tumor suppressing genes also known as Anti - oncogenes are the regulatory genes which regulates…
Q: A research study indicated that an agent in cigarette smoke caused the silencing of a tumor…
A: The TP53 gene provides instructions for making a protein called tumor protein p53 (p53). This…
Q: Imagine that you are a scientist who wants to better understand the genetic mechanisms underlying…
A: Mus musculus is an experimental model organism that allows researchers to test the role of certain…
Q: Much remains unknown about the rapid, uncontrolled growth, or what causes a tumor to metastasize.…
A: Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue. A…
Q: In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an…
A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…
Q: How might stem cells be used to repair brain or heart damage, even though these cells do not undergo…
A: Differentiation is important because specialized cells are used up, damaged or die all the time…
Q: Why would a mutation in BRCA1 be considered a driver mutation? b. Based on what you’ve learned…
A: In this question, we have to answer 'BRCA gene consider as driver mutation and ATM consider as a…
Q: How Mutations Cause Cancer Phenotypes?
A: The medical condition of cancer is generally characterized by the presence of a cluster of cells…
Q: Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger…
A: Hematologic childhood cancer can develop in any part of the body, including the blood and lymph…
Q: Do more mutations necessarily mean that more cancer-causing genes are faulty? Why or why not?
A: Biotechnology is a wide range of studies where it uses its techniques with biological systems to…
Q: Why is cancer a disease of individual cells? Because cancer involves cell proliferation None of the…
A: Cancer is defined as uncontrolled division of cells.
Q: Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene…
A: An oncogene helps in control cell division and contributes to cancer progression whereas a tumor…
Q: What is the difference between a proto-oncogene and a tumor suppressor gene? How can mutations in…
A: Proto-oncogenes are normally switched off. But when they get activated they cause tumors. On the…
Q: Why don’t all loss-of-function mutations that are recessive at the cellular level behave as…
A: Loss of function mutation is otherwise known as inactivating mutations. This type of mutation is…
Q: Can restoring tumor suppressor function, such as mutant p53 or pRb, be used to cure cancer? If…
A: The Cell division is the process through which one cell divides into two identical daughter cells.…
Q: How tumor-suppressor mutations contribute to cancer?
A: Cancer - Cancer is a type of disease in which cells divide in an uncontrolled manner. The cells…
Q: What were the key findings after modeling cancer through the generation of induced pluripotent stem…
A: The genetic information can be stored in the form of DNA, which may be converted into functional…
Q: How would our understanding of this regulation affect cancer prognosis and treatment?
A: The epithelial-mesenchymal transition (EMT) is a complex developmental process that allows cancer…
Q: Radiotherapy (treatment with ionizing radiation) is one of the most effective current cancer…
A: A Radiation therapy is used to treat cancer. This therapy uses intense energy like X-rays to target…
Q: n of tu
A: Tumour suppressor genes can be defined as the gene that is involved in the regulation and…
Q: Do mutations that cause cancer in an individual pass down to his/her offspring? What is the role of…
A: Cancer is the umbrella term for a group of diseases. Any of the body's cells begin to divide without…
Q: Is PI3K a proto-oncogene or a tumor suppressor gene? Why
A: PI3K means Phospho inositol 3 kinase gene.It is involved in signalling pathways.It is the mutation…
Q: a. How could you use sequence analysis to determine if this patient inherited the mutation from one…
A: There are various diagnostic technique used to diagnose cancer and they are:- Biopsy, Breast MRI,…
Q: How do we know that malignant tumors arise from a single cell that contains mutations?
A: Malignant tumors are multicellular cell masses invading normal tissues and disrupting their function…
Q: In cell growth, how does the normal allele of BRCA1 work? Is it an oncogene or a tumor suppressor…
A: Cell growth is a very complex and orderly process in which various enzymes cell signaling pathways…
Q: Can you think of two ways in which the function of p53 can be disrupted?
A: P53 is a tumor suppressor gene which normally restrains growth and mutation in this causes loss of…
Q: One major goal of modern cancer therapy is toidentify small molecules—anticancer drugs—that canbe…
A: Anticancer drugs are used against cancer. Chemotherapy drugs kill cancer cells by stopping them from…
Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
A: induced pluripotent stem cells are the type of stem cells that are produced from the somatic cells…
Q: Would a drug that induced apoptosis or one that induced necrosis be preferable for treatment of…
A: INTRODUCTION Flowcytometry Flowcytometry is a technique that simultaneously measures and analyse…
Q: Imagine you have used cBioportal and breast cancer patient datasets and identified a…
A: Introduction :- Cancer is defined as the uncontrolled and un-regulated proliferation of cells , due…
Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how can this be?
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?Can restoring tumor suppressor function, such as mutant p53 or pRb, be used to cure cancer? If that's the case, how is it possible?
- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings.What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.How can a defect in p53 gene contribute to cancer development?
- What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to cancer?Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please explain in detailsA research study indicated that an agent in cigarette smoke caused the silencing of a tumor suppressor gene called p53. However,upon sequencing, no mutation was found in the DNA sequence for this gene. Give two possible explanations for these results.