Answered: Can we treat cancer by restoring tumor…

Science

Biochemistry

Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how can this be?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Related questions

Q: How can a defect in p53 gene contribute to cancer development?

A: Cancer is an abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some…

Q: If you were to design an experiment to get p53 back into cancer cells, how would you go about that…

A: p53 Is a nuclear transcription factor that promotes apoptosis. Because over 50% of human cancers…

Q: Why are some chromosomal regions amplified/deleted in a specific manner in certain tumor types?

A: Chromosomal amplification: Chromosomal amplification can be explained as the increase in the amount…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…

A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…

Q: The rb gene encodes a protein that inhibits E2F, a transcriptionfactor that activates several genes…

A: Abnormal and unnecessary growth of cells termed cancer. Mutations in DNA causes cancer. In the…

Q: Cancer cells generally have missense mutations in p53 gene, resulting in truncated p53 normally…

A: A normal cell is converted into a cancer cell when the there is deactivation of the tumor suppressor…

Q: Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb?…

A: Cell division is a process through which a cell produces two identical daughter cells. Cell division…

Q: What are Two kinds of cancer-producing mutations?

A: Cancer is defined as any one of a large number of diseases characterized by the development of…

Q: Could a gene be involved in the growth of both stem cells and some kinds of cancer? Explain your…

A: in stem cells we have an important class of genes called proto-oncogenes [PO] with are necessary for…

Q: If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking…

A: Tumor is a mass of tissues. It may be benign or malignant. The cellular growth that occurs when the…

Q: Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell…

A: Need to find all the options that produce uncontrollable cell division and to increase chance of…

Q: Why do mutations in DNA repair genes increase the likelihood of developing cancer?

A: Deoxyribonucleic acid (DNA) is a hereditary molecule that transfers genetic information from one…

Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…

A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…

Q: Some cancers show increased incidence with age while others peak at younger ages. Why do you suppose…

A: The Cancer is defined as a group of diseases which is characterized by the uncontrolled growth and…

Q: The current way to gauge the effectiveness of chemotherapy is to track the size of the tumor. If the…

A: Introduction : The use of different combination of drugs in the treatment of cancer is referred to…

Q: Explain the role of epigenetic alterations in cancer ?

A: Genes are the hereditary unit in an organism and are passed on from the parental generation to the…

Q: Which is a.) Reduction of cancer risks b.) Correction of cancer genes or c.) Destruction of cancer…

A: Cancer is a disease caused by the uncontrolled proliferation of cells due to the defects in the cell…

Q: How can cancer arise from stem cells?

A: Stem cells are unique human cells and can grow into several cell types. This can vary between cells…

Q: Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene…

A: Tumor-supressor genes: Tumor-suppressor genes is defined as normal genes that will slow down the…

Q: Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop…

A: Cancer refers to the uncontrolled cell division caused by the mutations in the genes which control…

Q: Despite all that we know about cancer today, some types of cancers are still increasing in…

A: Cancer is the title given to a collection of related infections. In all sorts of cancer, a few of…

Q: What are some examples of genes involved in cancer?

A: Cancer is a clinical condition in which there occurs abnormal cell division leading to the formation…

Q: How can a mutation in a tumor-suppressor gene contribute to the development of cancer?

A: Tumor-suppressor genes are like any other normal genes whose functions include slowing down cell…

Q: Cancer is caused by many different types of gene mutations. Some mutations are in proto-oncogenes,…

A: Cells split into new cells so that the body uses them and cancer starts with this wonderful…

Q: You decide to have your genome sequenced. The results come back and show that you have a…

A: Any abrupt change in the DNA causes mutation. This may or may not change the function of the cell.…

Q: A research study indicated that an agent in cigarette smoke caused the silencing of a tumor…

A: The TP53 gene provides instructions for making a protein called tumor protein p53 (p53). This…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Question

Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how can this be?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

Unlike many other diseases, the vast majority of cancers in humans are not transmissible - meaning a person can’t ‘catch cancer’ from someone else. How does a person get cancer, then? Starting with a normal (non-cancerous) cell, describe a possible sequence of events that could eventually result in metastasized cancer, including the genes, structures or processes involved.
According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop. Once an oncogene has been formed by a mutation, what other type of gene must also mutate?
How do normal cells protect themselves from accumulating mutations in genes that could lead to cancer? How do cancer cells differ from normal cells in these processes?
In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoning
The Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6 and E7 proteins govern the cell via altering cellular proteins. The E6 protein interacts with the tumor suppressor protein p53 and directs its ubiquitin-mediated destruction. Can you elaborate about the P63 gene: its function and if it can be altered/mutated by HPV? If it does, what is the relationship between P53 and P63? Thank you!
Cancer can arise spontaneously, but it can also be induced as a result of environmental factors such as sun exposure, infections, and tobacco smoking. If you were asked to help allocate resources to cancer research, what emphasis would you place on research to find cancer cures, compared to that placed on education about cancer prevention?
How Mutations Cause Cancer Phenotypes?
Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger mutations that are along for the ride. Just because the tumors with a strong environmental component possess a higher frequency of mutations does not mean more oncogenes or more failure of tumor suppressors is occurring. Hematologic childhood cancers have a lower frequency of mutations than tumors with a strong environmental component such as lung cancers and melanoma; WHY?
Acquired mutation in the p53 gene is the most common genetic alteration found in human cancer (> 50% of all cancers). A germline mutation in p53 is the causative lesion of Li- Fraumeni familial cancer syndrome. In many tumors, one p53 allele on chromosome 17p is deleted and the other is mutated. What type of protein is encoded by the p53 gene? (A) Caspase (B) DNA repair enzyme (C) Membrane cell adhesion molecule (D) Serine phosphatase (E) Telomerase (F) Transcription factor (G) Tyrosine kinase
Do more mutations necessarily mean that more cancer-causing genes are faulty? Why or why not?
Hi, can you elaborate about these two concepts: 1) Can telomere inhibition be good cancer treatment? 2) Can cancer steam cells hypothesis be a good / bad approach?
Let’s suppose you were interested in developing drugs to preventepigenetic changes that may contribute to cancer. What cellularproteins would be the target of your drugs? What possible sideeffects might your drugs cause?