Concept explainers
a.
To determine: The reason behind the father not developing retinoblastoma.
Introduction: Cancer is defined as the condition in which the cells start showing abnormal and uncontrolled growth. The main cause of this condition is due to the mutation in cells. These mutations affect the contact inhibition amongst cells. Retinoblastoma is cancer of eyes in which the retinoblast cells grow uncontrollably.
b.
To determine: The chance that the couple will have another child carrying the mutant allele.
Introduction: The hereditary form of cancer is responsible for bilateral retinoblastoma. Bilateral retinoblastoma is caused due to a mutation in the RB1 gene. This type of cancer occurs due to a mutation in the tumor-suppressing gene and the homozygous condition is required for cancer to occur
c.
To determine: Whether there a benefit to knowing that the son in the given case may develop retinoblastoma.
Introduction: The hereditary form of cancer is responsible for bilateral retinoblastoma. Bilateral retinoblastoma is caused due to a mutation in both the RB1 genes in a person. This type of cancer occurs due to a mutation in the tumor-suppressing gene and the homozygous condition is required for cancer to occur
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Human Heredity: Principles and Issues (MindTap Course List)
- Hemophilia A is caused by a recessive X-linked allele that encodes a defective form of a clotting protein. If a affected father and a mother who is known to not be a carrier have children, what percentage of female offspring will have hemophilia?arrow_forwardO. 2 Hemophilia A is an X-linked trait where blood clotting is affected due to a mutation in a clotting factor protein. Georgio has hemophilia and attends a support group where he meets Gbenga, who does not have the disease, but whose father has hemophilia. Her mother is not affected. A) If they marry, what percentage % of all their children will have hemophilia? % B) Georgio meets another woman, Maria, at the hemophilia support group. Maria also lacks the trait, but her mother has hemophilia while her father is unaffected. # 3 Would a Georgio-Maria mating provide a larger chance of having afflicted children compared to a Georgio-Gbenga mating? C) Show how you came up with your answer to B. Edit View Insert Format Tools Table 12pt ✓ 80 F3 V Paragraph ✓ $ 4 Yes or No 000 000 F4 DO LO % 5 BIUAV T² | F5 ^ MacBook Air 6 2 F6 V & 7 F7 * 8 DII F8 ( 9 DD F9 1 0 S Farrow_forwardUse the pedigree to answer the questions that follow. Make sure you put your answer in the correct blank. A) AB В 1 5 II A A AB B A AB A 3 5 6 7 8 II A A B 2 3 5 6 a) State the possible blood type(s) of individual I-4 b) State the possible blood type(s) of individual I-6 c) State the possible genotype(s) of individual Il-5 d) State the possible genotype(s) of individual II-6 e) Determine the percentage chance that couple Il-4 and Il-5 have another child that has type O blood 2.arrow_forward
- Another couple is concerned their child will be born with sickle cell anemia. The woman does not have sickle cell anemia. The woman’s mother had sickle cell anemia and her father was a carrier of the sickle cell gene. The man knows that he is not a carrier of the sickle cell gene. What is the probability that the child will be a carrier of sickle cell anemia?arrow_forwardPancreatic cancer is clearly inherited as an autosomal dominant trait in the family illustrated in Figure 23.1. Yet most cases of pancreatic cancer are sporadic, appearing as isolated cases in families with no obvious inheritance. How can a trait be strongly inherited in one family and not inherited in another?arrow_forwardA woman is a carrier for hemophilia as well as red-green colorblindness. She has one son that has hemophilia, then one son that is colorblind. Several years later, she has a daughter that has symptoms consistent with hemophilia as well as an attenuated color blindness. How would this come about? (Draw a diagram…) Explain you answer step by step.arrow_forward
- Rh factor is a protein that can be found on the surface of red blood cells. If your phenotype is Rh+ you have this protein on your red blood cells. If your phenotype is Rh-, then you do not have this protein on your red blood cells. Rh factor follows simple Mendelian genetics, meaning if you are Rh positive you can have the genotype Rh+Rh+ or Rh+Rh-. If Ruby's genotype is IBiRh-Rh-, and Sam's genotype is IAIARh+Rh-, what is the probability that their baby will be type AB+?arrow_forwardChris does not have an RB1 mutation, and is therefore homozygous wild-type. Julie is heterozygous for the mutation. However, Kay has inherited a different RB1 mutation than the one her mother carries. Therefore, Kay did not receive her mother’s mutant allele. Assuming that Chris really is the father, what other explanation might there be for how she got a germline mutation?arrow_forwardA polydactylous, normal-visioned, brown-eyed man with wavy hair has a nonpolydactylous, blue-eyed mother. He proposed marriage to a nonpolydactylous, astigmatic, blue-eyed, and curly-haired lady whose mother has normal vision. However, the lady is worried about the proposal since sickle-cell anemia has been known to run in both their families. a. Is there a genetic basis for her worry? Explain. b. If it turned out that the lady is a carrier and the man has normal RBC, what would be their COMPLETE genotypes? Male genotype:Female genotype: c. Based on their genotypes, what is the probability that they would have: c.1 a child homozygous for normal RBC? c.2 nonpolydactylous child with normal vision? c.3 polydactylous, astigmatic child and sickle-trait carrier? c.4 a boy with his father’s genotype? c.5 a girl with her mother’s genotype?arrow_forward
- A) A woman with type O blood is expecting a child. Her husband is type A and her husband's parents both had type AB blood. What will be their child’s blood type? 2. A)A woman with type O blood is expecting a child. Her husband is type A and her husband's parents both had type AB blood. What will be their child’s blood type? B) A couple has one child with type AB blood. If one parent is heterozygous for blood type A and the other parent is homozygous for their blood type, what are the chances of their future children having: Type A blood? Type B blood? Type AB blood? O blood?arrow_forwardA man and a woman have a child with cystic fibrosis. Neither parent has cystic fibrosis. How could this happen? a) Both parents carry the cystic fibrosis allele, and each passed that allele to their child. b) The child had a spontaneous mutation on both copies of their CFTR alleles, leading to cystic fibrosis. c) One parent gave the child two copies of the cystic fibrosis CFTR allele. c) One parent gave the child a wild type CFTR allele, and the other parent gave them a cystic fibrosis CFTR gene.arrow_forwardThe mother of a family with 10 children has blood typeRh+. She also has a very rare condition (elliptocytosis,phenotype E) that causes red blood cells to be oval rather than round in shape but that produces no adverseclinical effects. The father is Rh− (lacks the Rh+ antigen)and has normal red blood cells (phenotype e). The children are 1 Rh+ e, 4 Rh+ E, and 5 Rh− e. Information isavailable on the mother’s parents, who are Rh+ E andRh− e. One of the 10 children (who is Rh+ E) marriessomeone who is Rh+ e, and they have an Rh+ E child.a. Draw the pedigree of this whole family.b. Is the pedigree in agreement with the hypothesisthat the Rh+ allele is dominant and Rh− is recessive?c. What is the mechanism of transmission ofelliptocytosis?d. Could the genes governing the E and Rh phenotypesbe on the same chromosome? If so, estimate the mapdistance between them, and comment on your resultarrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning