Concept explainers
(a)
Interpretation:
The formula for given set of compounds should be identified.
Concept introduction:
If a base receives one proton, then the formed species is a conjugate acid whereas an acid lose one proton, then the formed species is a conjugated base.
(b)
Interpretation:
The formula for given set of compounds should be identified.
Concept introduction:
If a base receives one proton, then the formed species is a conjugate acid whereas an acid lose one proton, then the formed species is a conjugated base.
(c)
Interpretation:
The formula for given set of compounds should be identified.
Concept introduction:
If a base receives one proton, then the formed species is a conjugate acid whereas an acid lose one proton, then the formed species is a conjugated base.
(d)
Interpretation:
The formula for given set of compounds should be identified.
Concept introduction:
If a base receives one proton, then the formed species is a conjugate acid whereas an acid lose one proton, then the formed species is a conjugated base.
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- Based on the following titration table of Glycine, would you be able to recreate the same for Histidine? Glicina Increasing pH H-N-CH,-COOH -H-N-CH,-co = H-N-CH,-C00- Net charge: +1 pH COOH-pKa = 2.3 NH3-pka = 9.6 CN AEq +1 +1 2.3 (0.5°-1)+(0.5°0)=-0.5 +0.5 0.5 9.6 -1 (0.5*+1)+(0.5°0)=+0.5 -0.5 1.5 14 Given that the pKas for Histidine are the following: pka1 = 1.82 pKa2 = 9.17 pКаз %3 6.00 pL = 7.59 2.arrow_forwardWhich of the following define the stereochemistry of alanine (as per the structure shown)? Note: Functional groups arranged horizontally are facing towards the front, and the functional groups arranged vertically are facing towards the back. a) d- b) S- c) R- d) I-arrow_forwardGiven the titration curve of the hypothetical polyprotic acid X at 0.100 M concentration (pKa1=4.0, pKa2=8.0, pKa3=12.0) titrated with 0.600 M NaOH, identify the pH at point C, H, E, and M.arrow_forward
- Based on the following titration table of Glycine, would you be able to recreate the same for Histidine? Increasing pH – Glicina H H-N-CH,-COOH = H-N-CH,-CO0- = H-N-CH,-coo- H H Net charge: +1 -1 pH COOH-pKa = 2.3 NH3-pKa = 9.6 CN ΔΕ +1 +1 2.3 (0.5*-1)+(0.5*0)=-0.5 +1 +0.5 0.5 9.6 -1 (0.5*+1)+(0.5*0)=+0.5 -0.5 1.5 14 -1 -1 2 Given that the pKas for Histidine are the following: pka1 = 1.82 pKa2 = 9.17 pКа3 %3D 6.00 pl = 7.59arrow_forwardwhat is the conjugate acid for the following reaction? HC2HO4 + H2O <--> H3O+ + C2HO4- A)C2HO4- B) HC2HO4 C)H2O D) H3O+arrow_forwardLet’s consider histidine as a free amino acid in aqueous solution. a) Draw the most likely structure of histidine under biochemical standard state conditions. b) Given that free histidine has the following three pKa values, assign each to its corresponding acidic hydrogen or conjugate base in your structure from part a). pKa1 = 1.7; pKa2 = 6.2; and pKa3 = 9.1 c) For each pKa, give the corresponding expression for the equilibrium constant. It helps to write out the chemical equation for each. d) Create a speciation diagram for histidine by plotting Xi vs pH from pH = 4 to pH = 8 where Xi is the mole fraction of the two histidine species involved in the K2 equilibrium in part c).arrow_forward
- Hypoglycin A, an amino acid derivative found in unripened lychee, is an acutely toxic compound that produces seizures, coma, and sometimes death in undernourished children when ingested on an empty stomach. (a) Draw the neutral, positively charged, and negatively charged forms of hypoglycin A. (b) Which form predominates at pH = 1, 6, and 11? (c) What is the structure of hypoclycin A at its isoelectric point?arrow_forward(a) Draw the structure of ninhydrin. (b)Write the complete equation for its reaction with amino acids. (c) What is the substance responsible for the purple colour produced upon reaction of ninhydrin with an amino acid?arrow_forwardWrite the structure of the following peptides: a) glycyl alanine b) tyrosyl alanyl glycine c) phenylalanyl tyrosyl seryl histidinearrow_forward
- Draw dipeptide Arg-Thr at pH 6.0. Circle the six atoms that are restricted in one plane. Calculate its approximate pI assuming pKa for NH3+ is 10.0, pKa for COOH is 3.0, PKR for Arg is 12.0arrow_forwardRefer to the following titration curve below: 13 12 11 10 9 7 6 5 4 3 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Volume of Titrant / mL - Unknown Acid 0.10 mol/L - titrant = NaOH 0.1 mol/L At ph 10.0, which form of histidine is most abundant? His2+ His- His° His+arrow_forwardA) Describe the glycosidic bond (using standard convention) indicated by “Arrow a.” B) Draw the open chain Fischer projection formula of the monosaccharide labeled “B” C) Describe the glycosidic bond (as in question A) indicated by “Arrow b.”arrow_forward
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