Human Anatomy & Physiology (2nd Edition)
2nd Edition
ISBN: 9780134553511
Author: Erin C. Amerman
Publisher: PEARSON
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Question
Chapter 10, Problem 1AYKA
Summary Introduction
To review:
The following:
a. Effects of curare, a poison that blocks binding of acetylcholine to its receptor at the neuromuscular junction.
b. Useful application for this type of poison.
c. The rationale behind the lethality caused by the overdose of this poison.
Introduction:
Acetylcholine is a neurotransmitter secreted by axons of the motor neurons in the synaptic cleft. This neurotransmitter is a ligand for the ligand-gated ion channels of the motor end plate. Its function is to create an action potential in the muscle after motor neuron receives stimuli. So, it is necessary for muscle contraction.
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Which of the following structures has activity like acetylcholine?
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The venom of many cobras contains a potent neurotoxin that binds to ligand-gated Na+ channels,causing them to open. Unlike ACh, which binds to and then rapidly unbinds from ligand-gated Na+ channels, the neurotoxin tends to remain bound to ligand-gated Na+ channels. How does this neurotoxin affect the nervous system’s ability to stimulate skeletal muscle contraction? How does it affect the ability of skeletal muscle fibers to respond to stimulation?
Which of the following structures has activity like acetylcholine?
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Chapter 10 Solutions
Human Anatomy & Physiology (2nd Edition)
Ch. 10.1 - What are the two types of striated muscle?Ch. 10.1 - Which two types of muscle are involuntary?Ch. 10.1 - What is the basic function of all types of muscle...Ch. 10.1 - 4. What five properties are common to all muscle...Ch. 10.1 - Prob. 5QCCh. 10.2 - Prob. 1QCCh. 10.2 - How are the terminal cisternae related to the...Ch. 10.2 - Prob. 3QCCh. 10.2 - How does the arrangement of myofilaments produce...Ch. 10.2 - 5. Describe the structure of a sarcomere. What is...
Ch. 10.2 - Prob. 6QCCh. 10.2 - Describe the structures of thin filaments, thick...Ch. 10.2 - Prob. 8QCCh. 10.3 - What is the resting membrane potential?Ch. 10.3 - Prob. 2QCCh. 10.3 - 3. How do the electrochemical gradients for...Ch. 10.3 - What two factors generate the resting membrane...Ch. 10.3 - What is an action potential?Ch. 10.3 - What happens during the two phases of an action...Ch. 10.4 - Prob. 1QCCh. 10.4 - Prob. 2QCCh. 10.4 - 3. How does excitation from a neuron trigger...Ch. 10.4 - How are excitation and contraction coupled?Ch. 10.4 - What are the steps of the crossbridge cycle?Ch. 10.4 - Prob. 6QCCh. 10.5 - What are the two immediate energy sources for...Ch. 10.5 - How long can these immediate energy sources fuel...Ch. 10.5 - Prob. 3QCCh. 10.5 - Prob. 4QCCh. 10.5 - Prob. 5QCCh. 10.5 - Prob. 6QCCh. 10.5 - Prob. 7QCCh. 10.6 - What is a twitch contraction?Ch. 10.6 - What are the phases of a twitch contraction?Ch. 10.6 - How does the timing of a stimulus impact the...Ch. 10.6 - 4. How do fused and unfused tetanus differ?
Ch. 10.6 - 5. At what length will a sarcomere be able to...Ch. 10.6 - How do type I and type II muscle fibers differ?Ch. 10.7 - Prob. 1QCCh. 10.7 - 2. Explain the process of recruitment.
Ch. 10.7 - Prob. 3QCCh. 10.7 - 4. How do isotonic concentric, isotonic...Ch. 10.8 - Prob. 1QCCh. 10.8 - Prob. 2QCCh. 10.8 - Prob. 3QCCh. 10.8 - What conditions does excess postexercise oxygen...Ch. 10 - Mark the following statements as true or false. If...Ch. 10 - How does a skeletal muscle fiber differ...Ch. 10 - Thick filaments are composed of the protein a....Ch. 10 - Prob. 4CYRCh. 10 - Prob. 5CYRCh. 10 - Mark the following statements as true or false. If...Ch. 10 - Prob. 7CYRCh. 10 - 8. Order the following events of excitation and...Ch. 10 - 9. Which of the following statements accurately...Ch. 10 - 10. A muscle fiber relaxes when:
a. the...Ch. 10 - Which of the following energy sources would...Ch. 10 - 12. Mark the following statements as true or...Ch. 10 - Prob. 13CYRCh. 10 - 14. Muscle tone is:
a. the result of voluntary...Ch. 10 - Prob. 15CYRCh. 10 - Which of the following is not likely to result...Ch. 10 - Which of the following factors is/are responsible...Ch. 10 - 18. What is thought to cause excess postexercise...Ch. 10 - Prob. 19CYRCh. 10 - 20. Which of the following best describes...Ch. 10 - Mark the following statements as true for smooth...Ch. 10 - Prob. 1CYUCh. 10 - Prob. 2CYUCh. 10 - 3. The drug neostigmine blocks the activity of...Ch. 10 - Explain why cardiac muscle cells and some smooth...Ch. 10 - Prob. 1AYKACh. 10 - Prob. 2AYKACh. 10 - Prob. 3AYKACh. 10 - Prob. 4AYKACh. 10 - Prob. 5AYKBCh. 10 - Prob. 6AYKB
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- b) scorpion, he felt numbness in his fingers due to the neurotoxin produced by the scorpion which is known to act on the voltage-sensitive sodium channels in excitable tissues, slowing the inactivation of sodium channels. potential Dr Honda Toyota caught a species of scorpion in the Sahara Desert. After handling the Predict how the venom would affect the duration and amplitude of an actionarrow_forwardBotulinum toxin (Botox) works by blocking the exocytosis of acetylcholine. A number of different medical and cosmetic procedures use this chemical. Injection of small quantities of botulinum toxin (Botox) into specific overactive muscles causes muscle relaxation that smooths the skin and reduces wrinkles. Injection into certain spinal ganglia helps reduce a certain form of chronic pain, and injections into the salivary glands causes the reduction of overactive saliva production. What type of toxin is Botox? a. Agonist b. Antagonistarrow_forwardBotulinum toxin (Botox) works by blocking the exocytosis of acetylcholine. A number of different medical and cosmetic procedures use this chemical. Injection of small quantities of botulinum toxin (Botox) into specific overactive muscles causes muscle relaxation that smooths the skin and reduces wrinkles. Injection into certain spinal ganglia helps reduce a certain form of chronic pain, and injections into the salivary glands causes the reduction of overactive saliva production. What type of toxin is Botox? Agonist or Antagonistarrow_forward
- Spastic paralysis (resulting from the failure of muscles to relax), induced by the neurotoxin strychnine, occurs when this poison blocks the binding of: the excitatory neurotransmitter acetylcholine to post-synaptic sodium channels the excitatory neurotransmitter glutamate to post-synaptic calcium channels the excitatory neurotransmitter serotonin to post-synaptic potassium channels the inhibitory neurotransmitter glycine to post-synaptic chloride channels the inhibitory neurotransmitter melatonin to post-synaptic bicarbonate channelsarrow_forwardNeurotransmitters, the chemicals used in signaling across synapses, can be either re-absorbed by the pre-synaptic neuron OR hydrolyzed after release by enzymes. Acetylcholine (ACh), the neurotransmitter at neuromuscular junctions, is broken down by the enzyme acetylcholinesterase (AChE) and then its component parts are re-absorbed. Sarin gas is an extremely dangerous neurotoxin that has been utilized in terrorism and chemical warfare. It is known as a "nerve gas" because it blocks AChE. Based on your understanding of the neuromuscular junction and hydrolitic enzymes, hypothesize how sarin gas le ads to paralysis and nerve damage in the people to whom it is exposed.arrow_forwardIf a patient was bitten by a poisonous spider (black widow) and the effects of its venom occurred at the neuromuscular junction in the peripheral nervous system, what neurotransmitter would be affected by this venom? And explain the mechanism of action of how the venom is a direct antagonist to this neurotransmitter.arrow_forward
- A patient has been exposed to the organophosphate pesticide malathion,which inactivates acetylcholinesterase. Which of the following symptoms would you predict: blurring of vision, excess tear formation, frequent or involuntary urination, pallor (pale skin), muscle twitching, orcramps? Would atropine be an effective drug to treat the symptoms?(See Clinical Impact 16.2 for the action of atropine.) Explain.arrow_forwardDescribe the effect of the botulinum toxin, which inhibits the release of acetylcholine at the neuromuscular junction. Would the poison curare, which competes for acetylcholine receptors (by attaching to the acetylcholine receptors and preventing acetylcholine from binding) have a similar effect? Explainarrow_forwardWhich of the following statements are true with regards to the differences between a neuromuscular junction, and a standard central nervous system (CNS) synapse? Select all that apply. O The neuromuscular junction is a synapse between a neuron (alpha motor neuron) and a muscle fibre. CNS synapses connect two neurons. The graded potential generated by a neuromuscular junction has a much larger voltage than that of a CNS synapse. The structure of the neuromuscular junction ensures that an action potential in the alpha motor neuron always results in an action potential in the post-synaptic muscle fibre. CNS synapses do not guarantee this. The neuromuscular junction always uses Acetylcholine as a neurotransmitter, whereas CNS synapses may use a variety of neurotransmitters depending on their location and functionarrow_forward
- Acetylcholine is a well known neurotransmitter at the neuromuscular junction (excitatory) and cardiac muscle (inhibitory). Explain how this works.arrow_forwardare these True or False? Receptors on the post-synaptic cell membrane that bind the acetylcholine are voltage-gated channels (channels that open in response to a change in the electrical charge of the membrane). When a muscle cell is not contracting its cell membrane is negative on the inner surface. The effect of a neurotransmitter on the muscle cell membrane is to modify its ion permeability properties temporarily.arrow_forwardName three ways to stop the effect of a neurotransmitteron the postsynaptic membrane. Give an example of each.arrow_forward
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