Which of the following statements is TRUE about NK cells?Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer.abCdNK cells mediate the rejection of MHCa bone marrow transplants into MHCª x MHCb F1 miceNK cells mediate the rejection of MHCa x MHC F1 bone marrow transplants into MHCa miceDetection of type I IFN (IFNa or IFNB) by NK cells decreases their cytotoxic capacityDown-regulation of MHC I molecules on target cells decreases NK cytotoxicity

Natural Killer (NK) cells are a type of cytotoxic immune cell that play a role in the rejection of…

Which of the following statements is TRUE about NK cells? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b C d NK cells mediate the rejection of MHCª bone marrow transplants into MHCª x MHC F1 mice NK cells mediate the rejection of MHCª x MHC F1 bone marrow transplants into MHCa mice Detection of type I IFN (IFNa or IFNB) by NK cells decreases their cytotoxic capacity Down-regulation of MHC I molecules on target cells decreases NK cytotoxicity

Which of the following statements is TRUE about NK cells? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b C d NK cells mediate the rejection of MHCª bone marrow transplants into MHCª x MHC F1 mice NK cells mediate the rejection of MHCª x MHC F1 bone marrow transplants into MHCa mice Detection of type I IFN (IFNa or IFNB) by NK cells decreases their cytotoxic capacity Down-regulation of MHC I molecules on target cells decreases NK cytotoxicity

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter42: The Immune System

Section: Chapter Questions

Problem 1VCQ: Figure 42.11 Which of the following statements about T cells is false? Helper T cells release...

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The following events elicit an antibody response to a T-dependent antigen (Ag). Put them in order and indicate which one would happen third (of the five answers as shown, not necessarily number 3 on a lecture slide or text diagram). O Ag-presenting cell displays Ag fragments next to self (MHC) molecule on its surface Helper T cell (TH) activates an appropriate B cell Helper T cell (TH) specific for the Ag binds to MHC-Ag complex B cell differentiates into a plasma cell; secretes antibodies specific for the Ag Ag-presenting cell phagocytizes Ag-carrying microbe
Write T if the statement is correct; write F if the statement is not correct. Antigen fragments that bind to MHC class I molecules are typically in endosomes. " " TAP1 and TAP2 are present on the plasma membrane of APCs. " " Proteasomes process antigens within the endoplasmic reticulum. " " Newly synthesized MHC class I molecules can be found within endosomes. " " Newly synthesized MHC class I α chains assemble in the ER with calnexin. " "
One of the following mismatches: Select one: CD4+ Cells/ T helper cells CD8+ cells/ MHC classII- bound antigens CD8+ cells/ Suppressor T cells Prothymocytes/ Thymus
CD8 T cells in a culture are analyzed for their ability to produce the cytokine IFN-g, and the numbers of IFN-g-producing CD8 T cells are quantified. As a control, T cells are also stimulated with an irrelevant non-viral peptide (ova) plus dendritic cells. The results are shown in the figure below. Why is the T cell response different between the two lymph node populations?
Cancer cells often underexpress MHC class 1 molecules. Due to these characteristics, they may be the target of: B cells Eosinophils Neutrophils NK cells OMacrophages
The following are steps in the cell-mediated inflammatory response. Put them in the correct order. 1. Activated macrophage cells release cytokines. 2. Antigen is engulfed and presented by a macrophage cell w/MHC II complex. 3. The TH1 cell's CD4 protein binds to the MHC II complex. 4. Phagocytosis and inflammation occur. 5. Th1 secrete TNF-alpha and other cytokines which activates the macrophage. A. 3, 4, 1, 2,5 В. 2, 3, 4, 5, 1 C. 3,5, 4, 1, 2 D. 2,3,5, 1, 4
Which two events are required to activate a cytotoxic T cell? There is more than one answer. O Class II MHC molecules present extracellular antigen for binding on a complementary cytotoxic T cell receptor. O IL-4 is released by a TH1 cell to be bound by a cytotoxic T cell. O Class I MHC molecules presents intracellular antigen for binding on a complementary cytotoxic T cell receptor O IL-2 is released by a TH1 cell to be bound by a cytotoxic T cell.
Indicate whether each of the cell components or processes given is involved the processing and presentation of exogenous antigens, endogenous antigens, or both. (Assume n cross-presentation here.) Exognenous Both Possible answers proteasomes MHC class II molecules No Answers Chosen No Answers Chosen phagocytosis or endocytosis invariant chains calnexin tapasin Endogenous No Answers Chosen vesicular transport from RER to Golgi lysosomal hydrolases TAP1 and TAP2 proteins MHC class I molecules
Which of the following statements are NOT TRUE about Antigen Presenting Cells (APCs)? (Select all that apply) An APC can become activated from antigen binding as well as MHC binding APCs can carry mutliple MHCs Antigen presenting is due to APC activation Adaptive, innate, and non-immune cells can be APCs APCs travel to the sites of resident macrophages to recruit effector immune cells An APC that binds via their expressed MHC II will be killed
Make an illustration that connects the events in inflammation mediated by chemical substances. Use the following words to come up with the output connected by arrows. 1. Modified proteins 16. C142356789 2. Kininogen 3. Prostaglandins 4. Clotting system 5. Antigen 17. Kallikrein 18. Platelets 19. Serotonin 20. Kinins 21. C1423 22. Anaphylotoxins 6. Lysosomal enzymes 7. Antibody 8. C1 9. Kallikreinogen 23. Chemotactic factor 24. Serum factors 10. C142 25. C14235 11. Antigen/Antibody 12. Cells migration 26. C1423567 27. Injurious stimuli 13. Histamine 28. Acute inflammation 14. Plasmin system 29. Increased vascular permeability 15. C3 30. Chronic inflammation
Why is the concentration of this ligand for the NK-cell receptor CD94:NKG2A. on the target cell an effective measure of the presence or absence of classical MHC class I molecules?
Determine which statement(s) are true/false NK cells are a type of lymphocyte involved in acquired immunity Plasma cells are a type of B- cell that directly bind antigens on target cells ✓ [Choose ] False True Binding of antigen to the cell surface of B-memory cells is a trigger for the secondary immune response Loss of MHC Class I expression would decrease the effectiveness of cytotoxic T-cell response [Choose ] [Choose ] [Choose ] >