Which of the following has the secondary property of positive allosteric modulation at nicotinic receptors? A) Galantamine OB) Memantine OC) Donepezil OD) Rivastigmine

When an elderly but active gentleman came in to collect his prescription for zopiclone (3.75mg at night), he seemed anxious and asked if it was longer acting than lormetazepam, whichwas his last hypnotic.He had asked his GP to change to a longer acting hypnotic because he was waking up in themiddle of the night to go to the toilet, not able to go back to sleep. The two hypnotics havesimilar properties but if anything the duration of action of zopiclone is slightly shorter.• The gentleman is 72; he lost his wife 10 months ago and is now living with his daughter’sfamily. She has two teenage girls.1: What issues would you want to explore?2: What would your advice be?3: Why do you think the GP changed the hypnotics?

Based on the transduction pathway presented above, what type of receptor is the beta-3 adrenergic receptor?   Question 15 options:   a)  It is a voltage-dependent ion channel.   b)  It is a G protein-coupled receptor (GPCR).   c)  It is a G protein.   d)  It is a protein kinase.   e)  It is a receptor tyrosine kinase (RTK).

In olfactory neurons, it is estimated that activation of the olfactory receptors results in an increase of roughly 200,000 molecules of cAMP per second. 1a) If an activated receptor produces one molecule of cAMP every 30 seconds, how many molecules of this receptor must be working in an activated neuron? How many G-alpha subunits are required in an activated neuron?  1b) If one receptor molecule is capable of activating 500 G-proteins, how many receptors will be activated?