When the amino acid levels in eukaryotic cells are low, general protein synthesis is reduced. Gcn4 translation, however, is increased. A. Why? B. In general, what is the mechanism by which Gcn4 levels are increased?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
When the amino acid levels in eukaryotic cells are low, general protein synthesis is reduced. Gcn4 translation, however, is increased.
A. Why?
B. In general, what is the mechanism by which Gcn4 levels are increased?
C. What would happen under high and low amino acid conditions if only one of the upstream ORFs were deleted from Gcn4?
D. What would happen under high and low amino acid conditions if all of the upstream ORFs were deleted from Gcn4?
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