WHAT IF? Suppose that instead of the PBDG receptor, the researchers hadused a receptor specific for a sweetener that humans crave but mice ignore.How would the results of the experiment have differed?
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WHAT IF? Suppose that instead of the PBDG receptor, the researchers had
used a receptor specific for a sweetener that humans crave but mice ignore.
How would the results of the experiment have differed?
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- Please ASAp. Thanku You discover a new species of frog in extremely dark parts of the Amazon rain forest. You hypothesize that this frog detects light using a mechanism similar to mammals. If you are correct, which of the following types of drugs would interfere with vision in this frog? (can choose more than one choice) a. TRPC blocker b.TRMP5 blocker c. CNG channel blocker d.PDE(phosphodiestrase inhibitor)WHAT IF? If you discovered a mutation in mice thatdisrupted the ability to taste sweet, bitter, and umamibut not sour or salty, what might you predict aboutwhere this mutation acts in the signaling pathways usedby these receptors?Recall that when we calculated the fraction of estrogen receptors occupied in the presence of 1 nM estradiol and 1 µM BPA, we found that the fraction of receptors occupied with estradiol was 0.14 and the fraction of receptors occupied with BPA was 0.71. Calculate the concentration of free receptor in terms of the total concentration of receptor, Rtotal 0.29R₁ total 0.86R total 0.85R total 0.15R total Confirm the approximate value for the dissociation Calculate the concentration of free estradiol in terms of the total concentration of receptor, Rtotal Confirm the approximate value for the dissociation constant for the estrogen receptor-estradiol complex.
- . MAKE CONNECTIONS How do the molecules thatactivate the vertebrate TLR signal transduction pathwaydiffer from the ligands in most other signaling pathways(see Concept 11.2)?The receptor or drug target in this case was the rat GABAA receptor obtained from homogenised rat brain cortical tissue. Using the same radioligand binding technique, what other way could you look at ligand affinity to GABAA receptors without using GABAA receptors derived from homogenised tissue and What are the advantages/disadvantages to each strategy?What is signal transduction? Illustrate and describe the molecular events in signal transduction pathways involving 1) G-protein-coupled receptors and 2) enzyme linked receptors.
- Q.2. Stevia, (Stevia rebaudiana), also called sweet leaf, flowering plant in the aster family (Asteraceae), grown for its sweet-tasting leaves and is used in place of table sugar. The global market for artificial sweeteners is greater than one billion dollars annually. Therefore, discovering compounds that tightly bind and activate the "sweet" receptors on the tongue can be a lucrative business. The sweet taste is quantified in units of "molar relative sweetness (MRS)" which is a measure that compares the sweetness of sugar substitutes to those of sucrose (table sugar). A. Identify the sweetening agent in Stevia and discuss its biochemical nature B. what is its MRS? And how it imparts sweetness?. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers design a drug that binds to PTGS1, but not to PTGS2.The receptor or drug target was the rat GABAA receptor obtained from homogenised rat brain cortical tissue. Using the same radioligand binding technique. what other way could you look at ligand affinity to GABAA receptors without using GABAA receptors derived from homogenised tissue??
- Give detailed Solution with explanation needed..don't use Ai answer this questionBriefly describe why there could be a possible link between TAS2R38 sensitivity and obesity. In your own words, formulate a summary (background, aim, method, results, conclusion) of a published study on obesity and taste receptors in your answer.Q1. Explain why GDP cannot dissociate from the alpha subunit of the Trimeric G-protein even though the receptor is activated by ligand binding and there is enough GTP for the exchange process.