what does the Hexa protein domain depict? (in relation with tay sachs disease) HEXA protein domain115, 153137 190224268328357382473 508$2984443PhamTwo domains were found on the HEXA sequence by SMART.Active siteGlyco hydro_20Two domains were found in HEXA protein by Pfam.Glycoside hydrolase family 20,Glycoside hydrolase family 20,catalyticdomaindomain 2ABNORMAL BREAKDOWN OF GM2 GANGLIOSIDE IN TAY-SACHS DISEASEGM2gangliosideLysosomes contain enzymes(like Hex A) that break downcompounds in the bodyGM2 gangliosideis broken downGM2 AgangliosideGM2 gangliosideis not broken downIn people with Tay-Sachsdisease, the Hex A enzymesin the lysosomesdo not function properlyGM2 ganglioside cannotbe broken down properlyand accumulatesin the brainFigure 8: Schematic view of abnormal breakdown of GM2ganglioside in Tay-Sachs disease.

Beta-hexoaminidase A is an enzyme that is present in the lysozyme. It breaks down a fatty substance…

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what does the Hexa protein domain depict? (in relation with tay sachs disease)

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter31: Completing The Protein Life Cycle: Folding, Processing, And Degradation

Section: Chapter Questions

Problem 15P

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Question

what does the Hexa protein domain depict? (in relation with tay sachs disease)

HEXA protein domain
115, 153
137 190
224
268
328
357
382
473 508
$29
84
443
Pham
Two domains were found on the HEXA sequence by SMART.
Active site
Glyco hydro_20
Two domains were found in HEXA protein by Pfam.
Glycoside hydrolase family 20,
Glycoside hydrolase family 20,
catalyticdomain
domain 2
ABNORMAL BREAKDOWN OF GM2 GANGLIOSIDE IN TAY-SACHS DISEASE
GM2
ganglioside
Lysosomes contain enzymes
(like Hex A) that break down
compounds in the body
GM2 ganglioside
is broken down
GM2 A
ganglioside
GM2 ganglioside
is not broken down
In people with Tay-Sachs
disease, the Hex A enzymes
in the lysosomes
do not function properly
GM2 ganglioside cannot
be broken down properly
and accumulates
in the brain
Figure 8: Schematic view of abnormal breakdown of GM2
ganglioside in Tay-Sachs disease.

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