What are the properties of the wild type amino acid, Tyrosine at position 368?  Hint: the amino acids are numbered in order starting at the N-terminus.

Draw the molecular formula of the covalently modifi ed histone side chain of acetyllysine. How does this modifi cation alter the chemical properties of the side chain?

Given the following diagram of how protein AWESOME1 binds to it's target DNA, describe the potential effects of each of the 5 mutations shown below. The wild-type sequence of a helix #1 is also shown in the blue box, and all the mutations are in helix #1 (see numbers for identifying particular residues). a helix #1 R(1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R(16) #1 Predict the consequence of the following mutations: 1) Arg(1) to Glu 2) Arg(1) to Ala 3) Phe(6) to lle 4) Trp(7) to Phe 5) Met(9) to Pro in