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The synthesis of phosphocreatine is unfavorable. If dur- ng extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1?

The synthesis of phosphocreatine is unfavorable. If dur- ng extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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(a) To illustrate how the ADP phosphorylative capacity was measured, the diagram below on the left shows a ³1P NMR spectrum of the arm of a control female subject at rest, and the diagram on the right the changes measured in the creatine and phosphocreatine levels of the arm at rest and exercise. PCr 10 Exer -cise Exer →→→Rest◄cise Rest PCr/Pi 9 PCr 15 20 10 Time(min) Isokinetic ergometer exercise of the control female subject showing intervals of rest and exercise. To obtain this graph, a ³1P NMR spectrum was col- lected every 2 min to show the changes in the PCr and Pi content of the arm skeletal muscle tissue. NH₂ during activity + ATP + C=NH2 during recovery YATP Pi GATP BATP SP 15 0 10 15 20 25 5 ppm 31P NMR spectrum of the arm of a control sub- ject at rest showing characteristic resonance features for the phosphate residues of ATP, phosphocreatine (PCr), and Pi. At rest the PCr/Pi ratio is ordinarily ~ 8-9. The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1? 0™ -0-P=0 N-H + C=NH₂2+ ADP CH3-N CH₂ COO™ Phosphocreatine CH3-N CH ₂ COO™ Creatine
Transcribed Image Text:(a) To illustrate how the ADP phosphorylative capacity was measured, the diagram below on the left shows a ³1P NMR spectrum of the arm of a control female subject at rest, and the diagram on the right the changes measured in the creatine and phosphocreatine levels of the arm at rest and exercise. PCr 10 Exer -cise Exer →→→Rest◄cise Rest PCr/Pi 9 PCr 15 20 10 Time(min) Isokinetic ergometer exercise of the control female subject showing intervals of rest and exercise. To obtain this graph, a ³1P NMR spectrum was col- lected every 2 min to show the changes in the PCr and Pi content of the arm skeletal muscle tissue. NH₂ during activity + ATP + C=NH2 during recovery YATP Pi GATP BATP SP 15 0 10 15 20 25 5 ppm 31P NMR spectrum of the arm of a control sub- ject at rest showing characteristic resonance features for the phosphate residues of ATP, phosphocreatine (PCr), and Pi. At rest the PCr/Pi ratio is ordinarily ~ 8-9. The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1? 0™ -0-P=0 N-H + C=NH₂2+ ADP CH3-N CH₂ COO™ Phosphocreatine CH3-N CH ₂ COO™ Creatine
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