The renal handling of a novel drug is being studied. When the drug is present in the blood, it is filtered into the Bowman’s capsule and secreted via transport proteins in the renal tubules, but it is NOT reabsorbed. The lines on the following graph represent filtration, secretion and excretion rates of this drug at various plasma concentrations.  For the three lines shown (labeled A-C) identify which line represents filtration, which line represents secretion, and which line represents excretion  Explain how you determined this.

Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter5: Urinalysis
Section5.4: Chemical Examination Of Urine
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The renal handling of a novel drug is being studied. When the drug is present in the blood, it is filtered into the Bowman’s capsule and secreted via transport proteins in the renal tubules, but it is NOT reabsorbed. The lines on the following graph represent filtration, secretion and excretion rates of this drug at various plasma concentrations. 

  1. For the three lines shown (labeled A-C) identify which line represents filtration, which line represents secretion, and which line represents excretion 
  2. Explain how you determined this. 

 

200
А
150
B
100
C
50
20
40
60
80
100
plasma concentration(mg/100mL)
filtration, secretion, excretion
rate (mg/min)
Transcribed Image Text:200 А 150 B 100 C 50 20 40 60 80 100 plasma concentration(mg/100mL) filtration, secretion, excretion rate (mg/min)
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