Question 7The malate transporter in the mitochondrial inner membrane is involved in two important biochemical processes: one catabolic, and one anabolic. What are they?Transport of NAD* from glycolysis from the cytosol to the matrix for oxidative phosphorylation, and the last step of glycolysisO A.The citric acid cycle, and the last step of glycolysisOB.The glycerol 3-phosphate shuttle system, and the first gluconeogenesis bypassTransport of FADH, from beta oxidation from the cytosol to the matrix for oxidative phosphorylation, and the first gluconeogenesis bypassOF Transport of NADH from glycolysis from the cytosol to the matrix for oxidative phosphorylation, and the first gluconeogenesis bypass

Malate-Aspartate shuttle is present on the inner membrane of mitochondria.

Answered: The malate transporter in the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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ATP synthesis in mitochondria requires all of the following EXCEPT (select two answers) a hydrogen ion concentration gradient across the inner mitochondrial membrane the oxidation of dinucleotide molecules that act as electron carriers fermentation of pyruvate into lactate to regenerate NAD+ the reduction O2, forming H2O the breakdown of glucose
The proton-motive force is a measure of the potential energy generated across the mitochondrial inner membrane during electron transport. Explain the factors that constitute this potential energy, that will be converted to the chemical energy of ATP by the cell
Which of the following conditions must be met within the cell In order for the enzyme pyruvate carboxylase to be activated? Select all that apply. NADP+ levels must be high Phosphofructokinase must be in the activated R-state Beta-oxidation of fatty acids happening in the mitochondrial matrix AMP levels must be high ATP levels must be high
Dinitrophenol (DNP) is a lipid soluble H+ binding drug that equalizes the H+ concentration across the inner mitochondrial membrane. Which of the following would you predict to occur upon addition of DNP to a cell? Halt in both pyruvate oxidation and ATP synthesis Halt in pyruvate oxidation and continuation in ATP synthesis Continuation in pyruvate oxidation and halt in ATP synthesis Continuation in both pyruvate oxidation and ATP synthesis
In the section dealing with “NAD+ in disease” it is mentioned that metabolomics resultsindicate that impaired mitochondrial function contributes to some of the mentioneddiseases. Which metabolites can potentially accumulate when complex I of theelectron transport chain is defective? Use Fig 1 for guidance
in the mitochondria pyruvate is converted into acetyl CoA so then acetyl CoA make its way to the TCA cycle and produces energy sources for oxidative phosphorylation. Pyruvate oxidation transforms pyruvate, a three-carbon molecule, into acetyl, a two-carbon molecule linked to Coenzyme A, generating NADH and releasing one carbon dioxide molecule in process the citric acid cycle is fundamental because runs on acetyl CoA as its fuel. i need more explanantion
Consider a liver cell carrying out the oxidation of glucose and fatty acids under aerobic conditions. Then, a very potent and specific inhibitor of the mitochondrial ATP synthase is added, completely inhibiting this enzyme. What will happen to the rate of the citric acid cycle? No change in the rate of the citric acid cycle O Increased due to the demand for reduced electron carriers to power reactions instead of ATP O Increased due to an accumulation of protons in the mitochondrial intermembrane space Reduced due to the accumulation of the products of the cycle that act as feedback inhibitors O Reduced as some enzymes of the cycle share the same active site as ATP synthase and will therefore be inhibited
Why can pyruvate cross the mitochondrial membrane but no other molecule after step 1 in glycolysis can?
Break down the glycolysis pathway in terms of the following reaction steps (you may write or take photos of chemical reactions; be sure to include the enzyme involved): - ATP-requiring steps - ATP-producing steps - NAD-involving steps, and - Irreversible steps
Yeast cells lacking the electron transport system still have a weak membranepotential across the mitochondrial inner membrane. How do these cells generatea membrane potential?
ADP and inorganic phosphate are provided for oxidative phosphorylation via an: ADP-ATP antiport and a proton-phosphate symport in the inner mitochondrial membrane. ADP-ATP antiport and a proton-phosphate symport in the outer mitochondrial membrane. O ADP-ATP antiport in the inner mitochondrial membrane and a phosphate uniport in the mitochondrial intermembrane space. ADP-phosphate symport in the inner mitochondrial membrane.
An important function of the inner mitochondrial membrane is to provide a selectively permeable barrier to the movement of water soluble molecules and thus to generate different chemical environments on either side of the mem- brane. However, many of the substrates and products of oxidative phosphorylation are water soluble and must cross the inner membrane. How does this transport occur?

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