Suppose replacing 1H127I with 2H127I. What changes would it be for the peak wavenumbers and for the spacing between adjacent peaks?
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Suppose replacing 1H127I with 2H127I. What changes would it be for the peak wavenumbers and for the spacing between adjacent peaks?
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- a.) Convert 5mM of K+ to mOsm b.) Interpret the effect of hyperkalemia with reference to the Nernst equation and EK+. What happens to EK+ if extracellular [K+] is elevated (and intracellular [K+] remains unchanged)? Make specific reference to the Nernst equation but there is no need to cite or calculate any specific numbers, just generalize the result.Give typing answer with explanation and conclusion Consider the following pharmacokinetic information: Desired AUC:MIC 400 mg/L x hr Vancomycin CL 2.5L/hr What dose would be required to have the desired AUC:MIC for a given patient?Crocodile hemoglobin does not bind 2,3-BPG. Instead, it binds bicarbonateion, which is a strong negative allosteric effector. Why might crocodileshave a hemoglobin that is responsive to HCO3- instead of 2,3-BPG? Recallthat crocodiles hold their prey underwater to kill them.
- If neurons fire action potentials when membrane potential reaches -50mV, how would hyperkalemia affect neuronal excitability (likelihood of the neuron firing action potentials)?The EC50 of an agonist for a GPCR is almost always (greater than, equal to, or less than) the KD of the same agonist at the same GPCR. Why?At what concentration of S(expressed as a multiple of KM) will νo=0.95Vmax?
- Assuming that the resting physiological cytoplasmic and extracellular concentrations of Ca2+ (Ca2+o=1 mM, Ca2+i=0.0001 mM ), Determine the Ca2+ equilibrium potential (VCa)Use the Goldman Equation to calculate the resting membrane potential at 37°C for each case:Systemic blood pressure is expressed as the ratio of the systolic pressure (when the heart first ejects blood into the arteries) to the diastolic pressure (when the heart is relaxed). Normal systemic blood pressure is 12080. What is the maximum force (in newtons) that the blood exerts against each square centimeter of the heart for a person with normal blood pressure?
- when calculating the Resting membrance potential using the goldman equation it is usally out, out , in / in, in, out. the cl- is switched so does that mean that when writing the in and out cellular concentartion should we still add negative sign in front of the value or since it is flipped we shouldnt?.After three minutes, the concentration of drug Zip in the red blood cells is 10 mmoles l-1. What is the average rate of entry of drug Zip into the red blood cells in units of moles min-1 red blood cell-1 during the first three minutes after placing the red blood cells into the bathing solution? Assume that each red blood cell occupies about 1 x 10-13 liters.assign KD to each ligand in the curve (0.03M, 0.005M, 0.015M, 0.045M)
