Some antibiotics act as carriers that bind an ion on one side of a membrane, diffuse through the membrane, and release the ion on the other side. The conductance of a lipid-bilayer membrane containing a carrier antibiotic decreased abruptly when the temperature was lowered from 40°C to 36° C. In contrast, there was little change in conductance of the same bilayer membrane when it contained a channel-forming antibiotic. Why?

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