Gleevec inhibits an enzyme needed in cancer cell proliferation. Itacts by increasing the enzyme's KM value without affecting kat. Thesolid line in the graph shows vo versus [S] without Gleevec. Which ofthe dashed lines shows the rate for the enzyme in the presence ofGleevec?A) IVB) VC) IID) IE) IIIvo (μM/s)12108420010IV20[S] (μM)250 500

Gleevec, also known by its trade name imatinib and internationally as Glivec, is an oral medicine…

Answered: Gleevec inhibits an enzyme needed in…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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You set up the following two tubes: Tube 1: 1mL of alkaline phosphatase + 4mL of 400 µM p-NPP Tube 2: 1mL of alkaline phosphatase + 4mL of 200 µM p-NPP Which tube would have a faster reaction rate? Explain your reasoning (why does concentration of p-NPP matter? Relate it back to week 4 lab concepts). Week 4 lab concepts: - concentration gradient - differentially permeable membrane - solute, solvent, diffusion, osmosis, hypotonic, isotonic, hypertonic, molarity, osmolarity
For an enzyme with a substrate Km of 0.001 M. a) What substrate concentration for an initial rate equal to one-half maximaly velocity? and b) for an initial rate equal to 0.9 maximal velocity> * a) [S} = 0.001 M, b) [S] = 0.009 M a) [S} = Km, b) [S] = 0.09 M a) [S] = 0.01 M, b) [S] = 0.9 M a) [S] = 1 M, b) [S] = 9 M
1. NSF is an enzyme that uses the energy of ATP hydrolysis to disassemble complexes between V-SNARES and t-SNARES. a) Why do you suppose such an enzyme is needed? b) If NSF were suddenly inactivated and then the cells were examined a short time later, what types of effects would you expect to see?
In the case of an enzyme that catalyzes a reaction at the diffusion limit, how quickly is the product generated in an aqueous solution containing 10 mM of enzyme and 1 mM of substrate? ?+? ⇌??→? a)74,000 M/s b)740 M/s c)7.4 M/s d)0.074 M/s
1:04 O • + Screenshot (11... / Checkpoint Which of the following are redox reactions? A. NH3 + HCI → NH,CI B. SO3 + H,O → H,SO4 C. Fe,03(s) + CO(g) → Fe(s) + CO2(g) For C... "What is reduced? What is oxidized?"
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Which of the following components of the ubiqutin-proteasome pathway are ATPases? (i.e., which consume ATP in order to function?) (Select all that apply) a)E3 ubiquitin-protein ligase b)19S proteasome c)20S proteasome d)E2 ubiquitin-conjugating enzyme e)E1 ubiquitin-activating enzyme f)Ubiquitin
Ms. Michi is a researcher in a renowned pharmaceutical company based in Singapore. One of the cell lines in the lab is suspected to be contaminated. She is culturing NIH 3T3 mouse embryo fibroblast cell line (NIH/3T3 (ATCC® CRL-1658TM). Figure 1 below illustrates her observation under the inverted phase contrast microscope. a) b) c) d) e) Figure 1 (Routray et al., 2016) What type of contamination is her laboratory facing? Explain your answer. Give FOUR (4) suggestions to Michi in order to prevent such contamination in future Besides the contamination stated in Question 2 a), name FIVE (5) other contaminations that Michi should be aware of. During a routine check, Michi's superior requests her to characterize cell lines available in the storage to determine their authenticity. Describe TWO (2) effective cell line characterization methods that she can utilize for this purpose. The pharmaceutical company wants to improve its toxicity testing by replacing monolayer culture with spheroid…
What regulatory mechanisms ensure that end-products and/or products of alternative pathways will not accumulate in cells? Provide 2
Regarding the use of animal cells in culture, it is correct to state that: * (a) Low cost culture media composed of mineral salts and amino acids are used (b) Cells must be kept in semi-solid media, allowing them to come into contact with the atmosphere rich in carbon dioxide. (c) Greenhouses with controlled temperature and atmosphere composed predominantly of carbon monoxide are used (d) On an industrial scale, culture media supplemented with serum of animal origin are used, which makes them media of indefinite composition (e) Culture media must not be sterilized by autoclaving, preferably filtration and/or ionizing radiation methods are used
Why is there a difference in the way these two kinds of cells react in a hypotonic solution?
Answer question in the photo

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